The Role of Histamine in Muscle Protein Synthesis Following Resistance Training

Not Applicable

Recruiting

• Conditions: Histamine
• Interventions: Drug: Placebo; Behavioral: Resistance training

• Registration Number: NCT06152497
• Lead Sponsor: University Ghent

Brief Summary

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-12-20
• Study Start: 2023-09-01
• Study First Submitted QC: 2023-11-29
• Study First Posted: 2023-11-30
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-06
• Last Update Posted: 2023-12-13
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

• Male
• 18-45 years
• Not to medium physically active

Exclusion Criteria

• Smoking
• Chronic disease
• High blood pressure
• Supplement or medication intake
• Seasonal allergies
• Vegetarian / vegan
• Resistance trained

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1: Placebo	Placebo	Lactose
1: Placebo	Resistance training	Lactose
H1 blockade: Telfast (180mg Fexofenadine)	Resistance training	H1: Telfast (180mg Fexofenadine)

Primary Outcome Measures

Name	Time	Method
Muscle volume	Before and after the 10 weeks of resistance training	Change in muscle volume
Maximal dynamic strength of leg press, bench press, bicep curl and leg curl	Before and after the 10 weeks of resistance training	Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl
Muscle fiber hypertrophy in muscle biopsies	Before and after the 10 weeks of resistance training	Change in muscle fiber hypertrophy in muscle biopsies
Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)	Before and after the 10 weeks of resistance training	Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)
Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)	Before and after the 10 weeks of resistance training	Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)

Secondary Outcome Measures

Name	Time	Method
Blood pressure (systolic and diastolic)	Before and after the 10 weeks of resistance training	Chance in Blood pressure (systolic and diastolic)
Resting heart rate	Before and after the 10 weeks of resistance training	Chance in Resting heart rate

Trial Locations

Locations (1)

Department of movement and sports sciences, Ghent University, Belgium; 🇧🇪 Ghent, Oost-Vlaanderen, Belgium