Heliox and Posture in Patients With Asthma

Not Applicable

Completed

• Conditions: Acute Asthma
• Interventions: Other: HELIOX; Other: HELIOX+POSTURE; Other: OXYGEN + POSTURE; Other: OXYGEN

• Registration Number: NCT00922350
• Lead Sponsor: Universidade Federal de Pernambuco

Brief Summary

The purpose of this study is to verify that nebulization with bronchodilators associated with heliox gas (helium + oxygen) and the posture of a leaning forward truck is effective in patients with an asthma attack.

Detailed Description

When associated with inhaled bronchodilators, the heliox, a mixture of helium and oxygen in obstructive lung diseases with asthma, reduces the turbulence of airflow despite high rates, due to its low density.

Although the first report of the use of heliox in the treatment of asthma dating to 1935, few controlled studies are available clarify the impact of the use of heliox in hospital admission of patients with acute asthma attacks refractory to standard treatment.

The severe airflow obstruction, observed in cases of acute asthma, also leads to lung hyperinflation that favors the increase of respiratory work by increasing the load for the inspiratory muscles by placing them at a mechanical disadvantage.

Various body positions were studied relating them to muscle activity with mechanical disadvantage. These studies suggest that the influence posture acts mainly in the position of the diaphragm, thus, increasing the stress related to other muscles such as the abdominals and the effect of gravity on these.

This study aims to: assess the efficiency of the positioning body associated with nebulization with bronchodilators carried by heliox during acute severe asthma in adults, using as the primary outcomes FEV1, FVC and PEF and secondary outcomes as the Borg scale, inspiratory capacity, RR, HR and SpO2.

Study Timeline

• Study Start: 2008-06
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Status Verified: 2009-06
• Study First Submitted: 2009-06-08
• Study First Submitted QC: 2009-06-16
• Last Update Submitted: 2009-06-16
• Study First Posted: 2009-06-17
• Last Update Posted: 2009-06-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

• reversibility of bronchial obstruction after administration of bronchodilator drugs for at least 10% in FEV1
• a clinical diagnosis of acute severe asthma
• a history of asthma over 1 year
• duration of the crisis of current asthma lasting less than seven days

Exclusion Criteria

• were unable to understand or perform the spirometric maneuver
• smoking (within the last 3 years associated with a higher consumption of 100 cigarettes/year)
• other pulmonary comorbidities
• lower to upper airways
• heart failure
• heart rate greater than 150 bpm
• systolic pressure below 90 mmHg or greater than 150 MHG
• pregnancy
• inability to stay inline with the trunk forward

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
heliox	HELIOX	The patients in this group underwent nebulization with heliox carried by the trunk erect
heliox+posture	HELIOX+POSTURE	The patients in this group carried out the mist carried by heliox and the trunk tilted forward
oxygen+posture	OXYGEN + POSTURE	The patients in this group carried out the mist carried by oxygen and the trunk tilted forward
oxygen	OXYGEN	The patients in this group carried out the mist carried by the oxygen and the trunk upright

Primary Outcome Measures

Name	Time	Method
Spirometry	6 months

Secondary Outcome Measures

Name	Time	Method
Respiratory rate	6 months
Peripheral oxygen saturation	6 months
Borg scale	6 months
Heart rate	6 months

Trial Locations

Locations (1)

Barros Lima Policlinic; 🇧🇷 Recife, Pernambuco, Brazil