Assessment of Pentraxin-3 Levels in Gingival Crevicular Fluid and Saliva in Periodontal Health and Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- GCF and salivary pentraxin-3 levels
研究概览
简要总结
Subjects were selected from the outpatient clinic, Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University. Ten healthy control subjects presented with clinically healthy periodontium. Ten patients who had plaque induced gingivitis. Ten patients who had generalized chronic periodontitis. Ten patients who had generalised aggressive periodontitis. Pentraxin-3 levels were evaluated in GCF and saliva of all subjects included in this study with ELISA technique.
详细描述
The study population consisted of 4 groups of forty patients selected as follows:
Group 1 - Healthy Controls:
Ten healthy control subjects presented with clinically healthy periodontium. Control subjects had to meet the following criteria for inclusion: probing depth less than 3mm, no clinical attachment loss, no bleeding on probing, with Gingival and Plaque index 0-1.
Group 2 - Plaque induced gingivitis patients:
Ten patients who had plaque induced gingivitis characterized by the presence of any of the following clinical signs: redness and edema of the gingival tissue, bleeding upon provocation, changes in contour and consistency, presence of calculus and/or plaque, with no clinical attachment loss nor radiographic evidence of bone loss.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with plaque induced gingivitis
- •patients with chronic periodontitis
- •patients with aggressive periodontitis
排除标准
- •Patients with any systemic disease according to Cornell medical index (1968).
- •Patients taking any medications or antibiotics in the last 3 months.
- •Current or former smoker patients.
- •Pregnant females.
结局指标
主要结局
GCF and salivary pentraxin-3 levels
时间窗: baseline
levels of pentraxin-3 in GCF and saliva
次要结局
- plaque index(baseline)
- gingival index(baseline)
- probing pocket depth(baseline)
- clinical attachment level(baseline)
研究者
Noha Ayman Ghallab
Professor of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University.
Cairo University