Impact of H1 Forel's field deep brain stimulation on Parkinson's disease gait disorders

Not Applicable

• Conditions: rigidity; Parkinson's disease; tremor; gait disorders; C10.228.140.079.862.500; C10.597.350.850; C05.651.504; C10.597.404

• Registration Number: RBR-9msccy
• Lead Sponsor: Hospital Santa Marcelina

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-06-10
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients diagnosed with Idiopathic Parkinson's disease according to the criteria of Queen Square Brain Bank; be over 35 years of age and less than 80 y-old; staging of Parkinson's Disease (Hoehn and Yahr scale), greater than 2 when evaluated in the absence of antiparkinsonian drugs effect; preserved clinical response to levodopa, the patient should present at least 30 percent reduction in the score of motor score the UPDRS scale; significant motor dysfunctions for 3 hours per day or more, despite the best drug treatment; persistent motor dysfunction for at least 1 month despite drug adjustment; patient's desire to receive deep brain stimulation as a therapeutic option in PD; adequate cognitive performance for the demand associated with the necessary care in the postoperative, with the DBS equipments, and in the recognition of adverse events; availability of the caregiver or family member, and of the patient himself, to come in frequent returns to ensure the best parameters of brain stimulation

Exclusion Criteria

Parkinsonism associated with other neurodegenerative diseases (multisystemic atrophy; dementia with Lewy bodies; corticobasal degeneration; frontotemporal dementia; spinocerebellar ataxia); vascular parkinsonism; parkinsonism associated with antidopaminergic drugs; normal pressure hydrocephalus; traumatic brain injury; previous surgical treatment for Parkinson's Disease (pallidotomy, thalamotomy, campotomy or deep brain stimulation); patients with uncompensated systemic pathology; Parkinson's disease associated psychosis; major depression according to DSM-IV criteria - American Psychiatric Association 2000; dementia associated with Parkinson's disease, according to the criteria of the Movement Disorders Society

Study & Design

• Study Type: Intervention
• Study Design: Not specified