Electrophysiological characterization of neuronal networks in tic patients with deep brain stimulatio

Not Applicable

Recruiting

Conditions: F95.1
F95.2
Chronic motor or vocal tic disorder
Combined vocal and multiple motor tic disorder [de la Tourette]

Registration Number: DRKS00029073

Lead Sponsor: Klinik für Stereotaxie und Funktionelle Neurochirurgie, Klinikum der Universität zu Köln

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

Fluent in the German language
- Age 18 to 65 years
- Chronic motor tic disorder (F95.1) or chronic motor and vocal tic disorder (F95.2) as main diagnosis according to the International Classification of Diseases 10 (ICD 10)
- Deep brain stimulation (Percept PC Neurostimulator)

Exclusion Criteria

- Active suicidal ideation
- Current psychotic symptomatology
- Active or recent substance abuse (except intake of cannabis-based substances, if consumed for treatment of tics)
- Serious systemic medical disease
- Severe neurological disorder of the central nervous system such as stroke, epilepsy, neoplasia
- Mental retardation
- Withdrawal of consent

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) Urge correlated connectivity between cortical areas (SMA, PFC, ACC) and the DBS target in the theta (4-8 Hz) and beta (15-30 Hz) frequency bands.

Secondary Outcome Measures

Name	Time	Method
2) Movement planning and movement execution-correlated connectivity between cortical areas (SMA, PFC) and DBS target in the delta (1-4 Hz) and theta (4-8 Hz) frequency band.<br>3) Connectivity between cortical areas (SMA, PFC, ACC) and DBS target in the delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and beta (15-30 Hz) frequency bands at rest.<br>4) Modulation of connectivity profiles in 1., 2., & 3. by THS.