Clinical and electrophysiological analysis of forel's field h1 deep brain stimulation on motor symptoms, cognitive variables and quality of life

Hospital Santa Marcelina0 个研究点开始时间: 2019年6月10日最近更新: 2023年5月29日

适应症

试验速览

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•Patients diagnosed with Idiopathic Parkinson's disease according to the criteria of Queen Square Brain Bank; be over 35 years of age and less than 80 y-old; staging of Parkinson's Disease (Hoehn and Yahr scale), greater than 2 when evaluated in the absence of antiparkinsonian drugs effect; preserved clinical response to levodopa, the patient should present at least 30 percent reduction in the score of motor score the UPDRS scale; significant motor dysfunctions for 3 hours per day or more, despite the best drug treatment; persistent motor dysfunction for at least 1 month despite drug adjustment; patient's desire to receive deep brain stimulation as a therapeutic option in PD; adequate cognitive performance for the demand associated with the necessary care in the postoperative, with the DBS equipments, and in the recognition of adverse events; availability of the caregiver or family member, and of the patient himself, to come in frequent returns to ensure the best parameters of brain stimulation

•Parkinsonism associated with other neurodegenerative diseases (multisystemic atrophy; dementia with Lewy bodies; corticobasal degeneration; frontotemporal dementia; spinocerebellar ataxia); vascular parkinsonism; parkinsonism associated with antidopaminergic drugs; normal pressure hydrocephalus; traumatic brain injury; previous surgical treatment for Parkinson's Disease (pallidotomy, thalamotomy, campotomy or deep brain stimulation); patients with uncompensated systemic pathology; Parkinson's disease associated psychosis; major depression according to DSM-IV criteria - American Psychiatric Association 2000; dementia associated with Parkinson's disease, according to the criteria of the Movement Disorders Society

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