Physical Activity and Food Intake Interaction: Effect of Weight Loss in Obese Adolescent

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Behavioral: Physical activity

• Registration Number: NCT02664844
• Lead Sponsor: University Hospital, Clermont-Ferrand

Brief Summary

In obese adolescents, energy expenditure (EE) of chronic high intensity muscular exercise (\> 70% VO2max) conducted one hour before a meal causes an anorectic effect at lunch and dinner the same day. The effect on food intake of the distribution of this exercise into two sessions during 24h remains to be determined. In addition, a multidisciplinary load of obesity generates a loss of body weight in the short term, which we do not know the effects on energy balance. To our knowledge, the impact of weight loss on the anorectic effect of muscle exercise is unknown.

Detailed Description

Two measuring sequences will be carried out before (M0) and after 4 months (M4) of a multidisciplinary treatment program of four months. Each sequence will have three days: a "sedentary" day (SED) and two days "exercise" (EX). During the exercise day "EX1", a continuous intense exercise will be conducted for 40 min at 70% VO2max of subjects. During the second day exercise "EX2" teenage realize two exercise representing the same DE as EX1 in the morning (50% ED) and late afternoon (50% ED). The multidisciplinary management program (without energy restriction) controlled by institution consists of nutrition education, physical activity and therapeutic education. The exercise program will involve the activity sessions controlled and supervised by a sports educator and interactive sessions using a scientifically validated physical activity program (Biomouv®).

Study Timeline

• Study Start: 2013-09
• Primary Completion: 2015-09
• Study Completion: 2015-12
• Status Verified: 2016-01
• Study First Submitted: 2016-01-15
• Study First Submitted QC: 2016-01-22
• Last Update Submitted: 2016-01-22
• Study First Posted: 2016-01-27
• Last Update Posted: 2016-01-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• Overweight adolescents (over the 90 th percentile of the international cut-off point)
• Sedentary (according to the IPAQ-A questionnaire)
• Without eating disorders (according to the DEBQ questionnaire)

Exclusion Criteria

• Medical or surgical antecedents that are incompatible with the study: cardiovascular, endocrine or digestive disease.
• Drugs that could interfere with the results of the study
• Surgical intervention in the 3 months
• Regular consumption of tobacco or Alcohol
• patients on a diet with caloric restriction
• Refusal to sign the consent form
• Regular practice of sport and intensive

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Obese adolescent	Physical activity	-

Primary Outcome Measures

Name	Time	Method
Comparison between(M0) and (M4) of food intake on 24 hours (total and per meal)	after 4 months of physical activity	Comparison between(M0) and (M4) of food intake on 24 hours (total and per meal) assessed during a day with the completion of intense exercise performed in one session EX1, in two sessions (EX2) or sedentary (without exercise: SED). The exercise-induced energy expenditure by 40 minutes at 70% of VO2 max is the same in EX1 and EX2.

Secondary Outcome Measures

Name	Time	Method
Comparison between(M0) and (M4) of the Flint scale	after 4 months of physical activity	Comparison between(M0) and (M4) of the Flint scale (feeling of hunger, desire to eat, the feeling of being full)
Comparison between(M0) and (M4) of the Pittsburg scale	after 4 months of physical activity
Comparison between(M0) and (M4) of HOMA-IR	after 4 months of physical activity	Comparison between(M0) and (M4) of HOMA-IR by measuring the blood glucose and fasting insulin
Comparison between(M0) and (M4) of Fitness	after 4 months of physical activity	Comparison between(M0) and (M4) of Fitness (by VO2 max and estimated body composition).

Trial Locations

Locations (1)

CHU Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France