Adductor-Canal-Blockade Versus the Femoral Nerve Block Effect on Muscle Strength, Pain and Mobilization After Total Knee Replacement

Not Applicable

Completed

• Conditions: Total Knee Arthroplasty

• Registration Number: NCT01470391
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The aim of this study is to investigate the efficacy of the Adductor-Canal-Blockade versus the Femoral Nerve Block on muscle strength, pain and mobilization after total knee arthroplasty. We hypothesize that the Adductor-Canal-Blockade has the same effect on pain and morphine consumption as the Femoral Nerve Block, but without the same reduction in quadriceps muscle strength.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2011-11-09
• Study First Submitted QC: 2011-11-09
• Study First Posted: 2011-11-11
• Primary Completion: 2012-11
• Study Completion: 2012-11
• Status Verified: 2012-12
• Last Update Submitted: 2012-12-17
• Last Update Posted: 2012-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• ASA 1-3
• BMI > 18 og < 40
• total knee arthroplasty in spinal anesthesia

Exclusion Criteria

• Can not cooperate to the exam
• Do not speak or understand Danish
• Drug allergy
• Alcohol or drug abuse
• Daily consumption of strong opioids
• Rheumatoid arthritis
• Intake of glucocorticoids
• Effect of spinal anesthesia stopped prior to performing the regional block

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
The difference in quadriceps muscle strength between the Adductor-Canal-Blockade and the femoral nerve block	24 h postoperatively

Secondary Outcome Measures

Name	Time	Method
The difference in adductor muscle strength between the Adductor-Canal-Blockade and the Femoral Nerve Block	24 h postoperatively
Pain during flexion of the knee	2-24 hours	0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively.
Pain at rest	2-24 hours	0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively.
Total morphine consumption	0-24 hours
Postoperative nausea	2-24 hours
Postoperative vomiting	0-24 hours
Sedation	2-24 hours
Zofran consumption	0-24 hours	Number of patients recieveing zofran postoperatively
The difference in mobilization between the groups	24 hours

Trial Locations

Locations (1)

Department of Anaesthesia, Copenhagen University Hospital, Frederiksberg; 🇩🇰 Frederiksberg, Denmark