Surgeon Infiltration QL Block Comparison

Phase 4

Completed

Brief Summary: The purpose of this study is to learn if using a Quadratus Lumborum (QL) plane injection technique (also called a "nerve block") that numbs the nerves going to the abdominal area improve pain control after surgery compared to administration of local anesthetic directly to the surgical incision. The QL block technique uses a numbing solution (local anesthetics) that is injected next to nerves located along muscles in the back to reduce pain. This block will not affect movement in the leg and/or make the legs weak. Some institutions, including Duke, use the QL block for patients having various abdominal surgeries, with the hope of providing good pain relief combined with improved mobility after surgery.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

ASA 3 or 5
Diagnosis of chronic pain
Daily chronic opioid use (over 3 months of continuous opioid use)
Inability to communicate pain scores or need for analgesia
Infection at the site of block placement
Pregnant women (as determined by standard of care day-of surgery urine bHCG)
Intolerance/allergy to local anesthetics
Weight <50 kg
Suspected or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years
Uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, may interfere with study assessments or compliance
Current or historical evidence of any clinically significant disease or condition that, in the opinion of the investigator, may increase the risk of surgery or complicate the subject's postoperative course

Arm && Interventions

Group	Intervention	Description
Quadratus Lumborum (QL) Block	QL Block	Patients will receive a bilateral ultrasound guided QL block by the anesthesia team.
Surgical wound infiltration	Liposomal Bupivicaine	Patients will receive 266 mg of liposomal bupivacaine mixed with 50 mg non-liposomal bupivacaine infiltrated into the wound by the surgeon.

Primary Outcome Measures

Name	Time	Method
Opioid Consumption in Oral Morphine Milliequivalents for the First 24 Hours After Surgery (Defined as 24 Hours After the Anesthesia End Time)	24 hours postoperatively

Secondary Outcome Measures

Name	Time	Method
Self-reported Numeric Pain Scores on Postoperative Day Seven	Postoperative day 7	Pain was measured on a self-reported scale of 0-10, where 0=no pain and 10=worst imaginable pain. Scores were gathered by phone on postoperative day 7.
Self-reported Ability to Walk for 15 Minutes Without Any Difficulty Within the First Postoperative Week	First seven days postoperatively	Physical function was assessed by daily phone interview during the first postoperative week. Subjects were asked to assess their ability to go for a walk of at least 15 minute on a scale of 1-5 with 1=unable to do and 5= able to do without any difficulty. For this outcome, the number of subjects who reported being able to go for a walk of at least 15 minutes "without any difficulty" at any time during the first postoperative week is reported.
Worst Bloating Severity in the First Postoperative Week	First seven days postoperatively	Bloating severity scores were gathered daily by phone interview for the first week postoperatively. Bloating severity was assessed on a scale of 1-5, where 1= not at all severe and 5=very much. The highest severity score reported during the week was collected for this outcome measure.

Receive instant email notifications about changes in this clinical trial

Receive instant email notifications about changes in this clinical trial