Metabolic Syndrome and Related Diseases in Healthcare Workers

Completed

• Conditions: Hyperlipidemia; Obesity; Diabetes Mellitus Type 2; Metabolic Syndrome X; Cardiovascular Diseases; Stroke; Hypertension

• Registration Number: NCT06543706
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

This study aims to investigate the incidence and prevalence of metabolic syndrome and metabolism-related diseases among healthcare workers, identify potential risk factors for these diseases, evaluate the control status of these conditions, and explore the significance of annual regular check-ups in improving metabolic-related health outcomes. All data for the study subjects are sourced from anonymized continuous records in hospital physical examinations and medical case files. The study does not involve any interventions. Upon obtaining the study data, researchers will use retrospective analysis methods to identify possible associations between risk factors and diseases.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-18
• Primary Completion: 2023-08-07
• Study Completion: 2023-11-10
• Status Verified: 2024-06
• Study First Submitted: 2024-06-06
• Study First Submitted QC: 2024-08-04
• Last Update Submitted: 2024-08-04
• Study First Posted: 2024-08-09
• Last Update Posted: 2024-08-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7432

Inclusion Criteria

• Age ≥18 years
• Healthcare workers who attend annual check-ups at Peking Union Medical College Hospital

Exclusion Criteria

• Presence of metabolic syndrome, hypertension, diabetes, coronary heart disease, or stroke at the time of the first physical examination between 2012 and 2022
• Malignant neoplasm
• Uremia
• Liver failure
• Moderate to severe heart failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
composite endpoint of cardiovascular and cerebrovascular diseases	through study completion, an average of 5 years	The number of hospitalizations due to severe coronary heart disease, stroke, or sudden cardiac death. The outcome is determined if any of the first three discharge diagnoses include acute myocardial infarction, stroke, or sudden cardiac death, or if an emergency coronary stent placement or coronary artery bypass graft surgery is performed during hospitalization.

Secondary Outcome Measures

Name	Time	Method
new-onset metabolic syndrome	through study completion, an average of 5 years	The number of individuals who did not meet the criteria for metabolic syndrome at the first examination but developed the syndrome later. The diagnostic criteria for metabolic syndrome involve meeting three or more of the following conditions: Abdominal obesity: waist circumference ≥90 (men) or ≥85 (women) cm. Hyperglycemia: fasting blood glucose ≥6.1 or 2-hour postprandial blood glucose ≥7.8 mmol/L or previously diagnosed diabetes. Hypertension: blood pressure ≥130/85 mmHg or previously diagnosed hypertension. Elevated triglycerides: fasting triglycerides ≥1.70 mmol/L or on lipid-lowering medication. Low fasting high-density lipoprotein cholesterol (HDL-C) \<1.04 mmol/L.; If waist circumference and HDL-C data are missing, abdominal obesity will be defined using the body mass index (BMI), calculated by dividing weight in kilograms by the square of height in meters (BMI ≥ 28.0 kg/m\^2). Total cholesterol ≥ 5.17 mmol/L will be used as a substitute for the HDL-C indicator.

Trial Locations

Locations (1)

Tengda Xu; 🇨🇳 Beijing, Beijing, China