Percutaneous cannulation of the thoracic duct in acute pancreatitis to achieve external lymph drainage

Not Applicable

Recruiting

• Conditions: Acute Pancreatitis; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12616000657426
• Lead Sponsor: The University of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-05-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

Project 1: Patients over 40 with acute pancreatitis admitted to Auckland City Hospital.

Project 2: Patients over 18 with acute pancreatitis exhibiting a SIRS response within 24 hours of admission to Auckland City Hospital.

Exclusion Criteria

*Pregnancy
*Concurrent MODS
*Requirement for either a central venous catheter or PICC line prior to thoracic duct cannulation
*Coagulopathy
*Patients actively bleeding
*Previous thoracic duct injury, intervention or ligation
*Previous left neck dissection
*Previous groin dissection
*Any skin or subcutaneous infection in the groin or antecubital fossa
*Previous deep vein thrombosis or pulmonary embolism
*Platelet count greater than 800
*Concurrent malignancy
*Previous mastectomy or axillary node dissection to the same side as proposed cannulation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Successful aspiration of lymph from catheter placed in the thoracic duct. <br><br>When the interventional radiologist believes the thoracic duct catheter has been correctly placed in the thoracic duct under fluoroscopic visualisation this will be confirmed by attaching a 5mL syringe to the end of the thoracic duct catheter. If lymph is aspirated this will confirm the correct placement of the catheter. [Aspiration of lymph at time of attempted thoracic duct cannulation.]

Secondary Outcome Measures

Name	Time	Method
Achieving 7 days of continual lymph drainage from the thoracic duct catheter without occlusion of the catheter. Occlusion will be assessed with firstly with heparinized saline flushing and if it does not resolve with contrast fluoroscopy. [7 days following cannulation if continual lymph drainage achieved<br>Time following cannulation that catheter becomes occluded.];Change in SIRS score from recruitment until the end of 7 days [7 days following cannulation];Change in APACHE II score from recruitment to the end of 7 days[7 days following cannulation];The change in serum CRP level will be calculated by subtracting the CRP level at 7 days following cannulation from the CRP on day of cannulation. [7 days following cannulation];Change in Modified Marshall score from recruitment until the end of 7 days.[7 days following cannulation]