Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.
- Conditions
- Epileptic Encephalopathy With Continuous Spike and Waves During Sleep (ECSWS)Benign Epilepsy With Centro Temporal Spikes (BECTS)Atypical Benign Partial Epilepsy (ABPE)
- Interventions
- Behavioral: Neuropsychological testingBehavioral: Neuropsychological procedureOther: Video EEG and polysomnography
- Registration Number
- NCT03865771
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information.
Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group.
Primary purpose:
To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group.
Secondary purposes:
* to study the evolution over time of memory consolidation
* to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 95
Principal:
- normal psychomotor development
- informed consent signed by both parents and subject if able
- affiliated to social security regimen
Specific
Patients from "severe" and "benign" groups:
- focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)
- children hospitalized for their follow-up
- normal neuroimaging
Control group
-children hospitalized for a non neurologic disease
Principal:
Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care
Specific
Patients from "severe" and "benign" groups:
- degenerative disease
- abnormal neuroimaging
- mental deficiency
Control group
- neurologic trouble
- abnormal sleep EEG
- intellectual deficiency
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CONTROL GROUP Video EEG and polysomnography Patients hospitalized for non neurologic illness (diabetes, nephropathy, chronic intestinal disease) Medical visit Neuropsychological testing Neuropsychological procedure Video EEG and polysomnography : 2h wake and whole night Sleep diary EPILEPSY GROUP Neuropsychological testing Patients with typical BECTS (benign group) or atypical BECTS or ECSWS (severe group) Medical visit Neuropsychological testing Neuropsychological procedure Video EEG and polysomnography (standard of care procedure): 2h wake and whole night Sleep diary CONTROL GROUP Neuropsychological procedure Patients hospitalized for non neurologic illness (diabetes, nephropathy, chronic intestinal disease) Medical visit Neuropsychological testing Neuropsychological procedure Video EEG and polysomnography : 2h wake and whole night Sleep diary EPILEPSY GROUP Neuropsychological procedure Patients with typical BECTS (benign group) or atypical BECTS or ECSWS (severe group) Medical visit Neuropsychological testing Neuropsychological procedure Video EEG and polysomnography (standard of care procedure): 2h wake and whole night Sleep diary CONTROL GROUP Neuropsychological testing Patients hospitalized for non neurologic illness (diabetes, nephropathy, chronic intestinal disease) Medical visit Neuropsychological testing Neuropsychological procedure Video EEG and polysomnography : 2h wake and whole night Sleep diary
- Primary Outcome Measures
Name Time Method memory lapse rate at 24 hours in the severe group, the benign group and the control group. ("memory lapse rate": rate of non recalled words number, during the delayed recall phase of the test, related to the maximal number of words recalled 24 hours
- Secondary Outcome Measures
Name Time Method memory lapse rate for each group at 1 hour, 5 hours, 24 hours Correlation of memory lapse rate with EEG severity scale, atypical criteria, EEG focus localization, sleep discharges frequency at 1 hour, 5 hours, 24 hours Correlation of memory lapse rate with Executive functioning tests scores at 1 hour, 5 hours, 24 hours Correlation of memory lapse rate with age of onset, epilepsy phase, treatment at 1 hour, 5 hours, 24 hours Correlation of memory lapse rate with number and organization of sleep cycles at 1 hour, 5 hours, 24 hours
Trial Locations
- Locations (2)
Hopital D'Enfants Pediatrie Medicale Ambulatoire
🇫🇷Nancy, France
Hopital de Hautepierre-Service de Pediatrie/Neurologie
🇫🇷Strasbourg, France