NCT04048681已完成不适用
Neurological Impacts of Artificial Sweeteners in the Context of Diet Sodas
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 2
- 主要终点
- Changes in Brain Response to Food Cues in the Insula
研究概览
简要总结
This study seeks to determine whether artificial sweeteners in the context of diet soda may alter the brain's response to food cues and thus impact appetite.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women who are 18-65 years old, with a BMI >30kg/m2.
排除标准
- •Unable or unwilling to participate in the study for any reason
- •Metal in the body or other safety concerns which makes patient unable to have an MRI
- •Pregnant women will be excluded to protect the fetus against potential effects of a non-medically required MRI on fetal development and difficulty of measuring accurate BMI.
结局指标
主要结局
Changes in Brain Response to Food Cues in the Insula
时间窗: 1 hour
Functional magnetic resonance imaging (BOLD signals) while patients view food vs. non-food cues. The effect size z-score represents the magnitude of the activation in that area to food cues vs. non-food cues. The z-score is the estimated response magnitude in that area compared to the overall mean. Negative numbers indicate values lower than the mean and positive numbers indicate values above the mean.
次要结局
- Neurocognitive Testing (Stop Signal Reaction Time)(1 hour)
研究者
Olivia Farr
Instructor in Medicine
Beth Israel Deaconess Medical Center
研究点 (2)
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