Systematic Follow-up of Patients Surviving an Episode of Acute Hypercapnic Respiratory Failure in the ICU

• Conditions: Acute Hypercapnic Respiratory Failure

• Registration Number: NCT02111876
• Lead Sponsor: Ligue Pulmonaire Genevoise

Brief Summary

There is currently no good description of patients surviving an episode of acute hypercapnic respiratory failure in the ICU. For instance, the prevalence of OSA and sleep hypoventilation in a stable clinical condition is not known in this population.

This prospective cohort describes the clinical profile, predictors of readmission (followed over a year), and the prevalence of sleep-related breathing disorders (polysomnography in a stable clinical condition 3 months after ICU discharge) in patients treated for an episode of acute hypercapnic respiratory failure in the ICU.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-09
• Study First Submitted: 2014-03-10
• Status Verified: 2014-04
• Study First Submitted QC: 2014-04-09
• Last Update Submitted: 2014-04-09
• Study First Posted: 2014-04-11
• Last Update Posted: 2014-04-11
• Primary Completion: 2014-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• > 18 years Informed consent surviving an episode of acute hypercapnic respiratory failure

Exclusion Criteria

• iatrogenic hypercpania pregnant woman

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sleep apnea syndrome	at 2 month after ICU discharge	Apnea-Hypopnea Index defined by polysomnography
Sleep Hypoventilation	at 2 month after ICU discharge	defined by AASM 2012 criteria with transcutaneous PtCO2 monitoring

Secondary Outcome Measures

Name	Time	Method
Lung physiology ( obstructive or restrictive lung disease)	at week 2 after ICU discharge	FEV1, VC, TLC, DLCO
Inspiratory Muscle Strength	at week 2 after ICU discharge	Sniff nasal maximal inspiratory pressure, Mouth inspiratory pressure
Cardiac function	at week 2 after ICU discharge	Systolic and diastolic cardiac function, pulmonary hypertension
Hospital and ICU readmission rate	1 year follow-up after ICu discharge

Trial Locations

Locations (1)

Hôpitaux Universitaires de Genpve; 🇨🇭 Geneva, Switzerland