Effect of collagen supplement and fish oil on gut microbiome

Not Applicable

Recruiting

Conditions: Condition 1: burns. Condition 2: burns. Condition 3: burns.
Burn and corrosion of trunk
Burn and corrosion of shoulder and upper limb, except wrist and hand
Burn and corrosion of lower limb, except ankle and foot

Registration Number: IRCT20131125015536N9

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 63

Inclusion Criteria

Burns of 20-45% of body surface area
Degree 2 (deep) or 3
18-60 years old men and women
The ability to oral intake up to 48 hours after admission

Exclusion Criteria

Past medical history of diabetes and other endocrine disorders, cancer , digestive disorders and malabsorption , cardiovascular and respiratory diseases, organ failure such as liver and kidney failure , infectious diseases, and autoimmune disease
History of allergy or intolerance to protein products
Pregnant or postmenopausal women
Smoking , addiction , alcohol cosumption
Taking NSAIDs and anticoagulant medications
Taking high doses of protein or omega-3 fatty acid supplements within 3 months prior to study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination and comparison of gut Lactobacillus between 3 study groups. Timepoint: before and after 2 weeks of intervention. Method of measurement: Real Time PCR.;Determination and comparison of gut Enterobacteriaceae between 3 study groups. Timepoint: before and after 2 weeks of intervention. Method of measurement: Real Time PCR.;Determination and comparison of gut Bifidobacterium between 3 study groups. Timepoint: before and after 2 weeks of intervention. Method of measurement: Real Time PCR.;Determination and comparison of gut Firmicutes / Bacteroidetes ratio between 3 study groups. Timepoint: before and after 2 weeks of intervention. Method of measurement: Real Time PCR.

Secondary Outcome Measures