The effect of collagen supplementation on collagen metabolism after total hip arthroplasty.
- Conditions
- Osteoarthritis of the hip
- Registration Number
- NL-OMON27884
- Lead Sponsor
- Maastricht University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
•Written informed consent
•With osteoarthritis and due for total hip arthroplasty
•= 60 years old
•BMI 18.5-35 kg/m2
Exclusion Criteria
•Taking medications known to influence protein metabolism
•Collagen allergy
•Diabetes mellitus
•Alcohol abuse
•Surgical intervention in past four weeks
•GFR <20mL/min/1.73m2
•Rheumatoid arthritis
•Collagen disorders
•Cancer
•Gastrointestinal disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main endpoints of this study are the changes in serum concentrations of biomarkers of collagen metabolism perioperatively and up to two weeks after surgery. These biomarkers represent bone and cartilage synthesis (N-terminal propeptide of type I and type II collagen, respectively: P1NP, P2NP) and breakdown (C-terminal telopeptide of type I and type II collagen, respectively: CTx1, CTx2).
- Secondary Outcome Measures
Name Time Method Secondary endpoints include changes in plasma amino acid concentrations and pain and functional outcomes.