The effect of collagen supplementation on collagen metabolism after total hip arthroplasty.

Recruiting

• Conditions: Hip osteoarthritis; Osteoarthritis of the hip; 10037008; 10023213; 10005944

• Registration Number: NL-OMON54316
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

• Written informed consent
• With osteoarthritis and due for total hip arthroplasty
• >= 60 years old
• BMI 18.5-35 kg/m2

Exclusion Criteria

• Taking medications known to influence protein metabolism
• Collagen allergy
• Diabetes mellitus
• Alcohol abuse
• Surgical intervention in past four weeks
• GFR <20mL/min/1.73m2
• Rheumatoid arthritis
• Collagen disorders
• Cancer
• Gastrointestinal disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoints of this study are the changes in serum concentrations of<br /><br>biomarkers of collagen metabolism perioperatively and up to two weeks after<br /><br>surgery. These biomarkers represent bone and cartilage synthesis (N-terminal<br /><br>propeptide of type I and type II collagen, respectively: P1NP, P2NP) and<br /><br>breakdown (C-terminal telopeptide of type I and type II collagen, respectively:<br /><br>CTx1, CTx2). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints include changes in plasma amino acid concentrations. </p><br>