Effects of collagen peptide supplementation on knee JOINT discomfort during and after repetitive low-INtensity exercise

Completed

Conditions: Gewrichtsaandoeningen
joint discomfort
Knee discomfort

Registration Number: NL-OMON42581

Lead Sponsor: Fysiologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

o Registration for the Nijmegen Four Days Marches 2016
o Self-reported activity-related knee discomfort (VAS score >=1)
o Between 50 and 75 years of age
o Willingness to provide written consent after proper information about the study objectives and procedures.

Exclusion Criteria

o A known systemic joint or muscle disease
o Individuals that follow a low protein diet for medical reasons due to known kidney disease.
o Disease influencing the uptake of protein (i.e. inflammatory bowel disease, Crohn*s disease)
o Vegetarian diet
o Diabetes mellitus (type 1 and type 2)
o Recent knee surgery (< 6 months)
o Use of statins or other medicines that influence muscle health
o Use of other dietary supplements for joint health (i.e. glucosamine, chondroitin)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome parameter is the difference in activity-related knee<br /><br>discomfort expressed by the VAS-score at baseline and after the intervention<br /><br>period/during the Nijmegen four-day marches. Furthermore, questionnaires,<br /><br>handgrip strength, muscle contraction characteristics, inflammatory markers and<br /><br>bone and joint markers will be assessed as secondary outcome parameters. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters/endpoints (if applicable)<br /><br>o (Changes in) activity-related knee discomfort expressed by and the KOOS<br /><br>score Lysholm score<br /><br>o Handgrip strength<br /><br>o Maximal voluntary strength of the quadriceps muscle<br /><br>o Fatigue-index and force-frequency relationship of the quadriceps muscle<br /><br>o Inflammatory markers (IL-6, IL-1beta, TNF-alpha, MCP-1, hsCRP)<br /><br>o Bone and joint markers (PINP, CTX, osteocalcin, CP2, CTXII)<br /><br><br /><br>Other study parameters (if applicable)<br /><br>o Subject characteristics (anthropometrics)<br /><br>o Protein intake (24h recall)<br /><br>o Physical activity (SQUASH) and exercise training (diary)<br /><br>o Liver and kidney health urine/blood parameters</p><br>