Effects of protein supplementation on knee complaints during and after repetitive walking exercise
Recruiting
- Conditions
- Knee joint discomfort in rest, during and after low-intensity exercise
- Registration Number
- NL-OMON25107
- Lead Sponsor
- Radboudumc Nijmegen, Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
o Registration for the Nijmegen Four Days Marches 2016
o Self-reported activity-related knee discomfort (VAS score ≥1)
Exclusion Criteria
o A known systemic joint or muscle disease
o Individuals that follow a low protein diet for medical reasons due to known kidney disease.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method (Changes in) activity-related knee discomfort expressed by the VAS-score (=∆VAS: baseline – 12 weeks of intervention)
- Secondary Outcome Measures
Name Time Method o (Changes in) activity-related knee discomfort expressed by and the KOOS score Lysholm score<br /><br>o Handgrip strength <br /><br>o Maximal voluntary strength of the quadriceps muscle (in only 40 subjects)<br /><br>o Fatigue-index and force-frequency relationship of the quadriceps muscle (in only 40 subjects)<br /><br>o Inflammatory markers (IL-6, IL-1beta, TNF-alpha, MCP-1, hsCRP)<br /><br>o Bone and joint markers (PINP, CTX, osteocalcin, CP2, CTXII)<br /><br>o Analgesics usage<br /><br>o Subject characteristics (anthropometrics)<br /><br>o Protein intake (24h recall)<br /><br>o Physical activity (SQUASH) <br>