To compare the efficacy of magnesium sulphate gargles and ketamine gargles on incidence and severity of post-operative sore throat following endotracheal intubation.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Post-operative sore throat
Study Overview
Brief Summary
Post-operativesore throat (POST) is a common adverse event after general anaesthesia. Thoughconsidered as a minor complication, it may cause significant post-operativemorbidity and patient dissatisfaction. Ketamine, an NMDA receptor antagonist,has been used as gargle, for reducing the incidence and severity of POSTfollowing endotracheal intubation. Magnesium sulphate, also an NMDA receptorantagonist has been recently used as gargle and found to attenuate POST moresignificantly than ketamine.This comparison has been made in patients in whomairway was secured using endotracheal tube. Our study was aimed at assessingand comparing the efficacy of magnesium sulphate and ketamine gargles onincidence and severity of post-operative sore throat following endotrachealintubation.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients requiring general anaesthesia with Proseal laryngeal mask airway.
- •Physical status ASA grade I and II.
Exclusion Criteria
- •1.Patients with history of pre-operative sore throat, asthma, COPD.
- •2.Patients requiring oropharyngeal, head and neck surgeries.
- •3.Patients with Body Mass Index > 30 kg/m
- •4.Patients with full stomach or abdominal distension.
- •5.Patients with gastroesophageal reflux disease.
- •6.Patients with modified mallampatti class IV, anticipated difficult airway.
- •7.Patients having allergy to study drugs.
- •8.Patients who have recently received NSAIDS.
- •9.Patients having nausea and vomiting.
- •10.Expected duration of surgery more than 2 hours.
Outcomes
Primary Outcomes
Post-operative sore throat
Time Frame: Assessed at 0, 2, 4, 24 hrs post-operatively & graded on a four-point scale
Secondary Outcomes
- Requirement of Analgesics for POST & Side Effects profile of study drugs.(VAS scoring POST to be assessed at 0,2,6,24 hours post operatively)