Synovitis in Patients With Osteoarthritis

Completed

• Conditions: Osteoarthritis, Knee
• Interventions: Procedure: Total knee arthroplasty due to advanced osteoarthritis.

• Registration Number: NCT05617573
• Lead Sponsor: The Affiliated Hospital of Qingdao University

Brief Summary

To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-01
• Study First Submitted: 2022-11-08
• Study First Submitted QC: 2022-11-08
• Study First Posted: 2022-11-15
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-02
• Last Update Posted: 2023-01-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 272

Inclusion Criteria

• patients undergoing elective, unilateral, primary TKA for advanced osteoarthritis.

Exclusion Criteria

• revisions, bilateral procedures, alcohol or medical abuse, administration of any glucocorticoids during the 3 months prior to surgery, and/or a history of serious cardiac or cerebrovascular problems, severe liver or kidney failure, and/or connective tissue disease including rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients undergone TKA due to advanced knee osteoarthritis	Total knee arthroplasty due to advanced osteoarthritis.	-

Primary Outcome Measures

Name	Time	Method
Correlation between pathological features and laboratory index	1 day
Correlation between pathological features and clinical scores	1 day.

Trial Locations

Locations (1)

The affiliated hospital of Qingdao University; 🇨🇳 Qingdao, Shandong, China