Lexical Priming by Music in Alzheimer's Disease and Healthy Aging

Not Applicable

Terminated

• Conditions: Alzheimer Disease
• Interventions: Other: Exposure to familiar songs; Other: Music Experience Questionnaire; Other: Implicit tasks memory; Other: Questionnaires

• Registration Number: NCT03342326
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

While verbal memory is quickly reached in the wake of Alzheimer's disease, the musical memory remains preserved until a late stage of the disease. This observation encouraged the development of music-based therapies in the management of neurocognitive and behavioral disorders that characterize Alzheimer's disease. In order to develop rehabilitation programs that effectively target cognitive functions to stimulate, it is necessary to understand the mechanisms underlying this beneficial effect of music on cognition.

Detailed Description

The investigators study the stimulation by the song, material integrating language and music, and having an autobiographical value. The investigators measure the lexical priming capacity of the song, that is, its ability to activate and maintain lexical and semantic representations, which are threatened with alteration in the course of the disease.

This lexical priming effect by song is measured in patients with mild Alzheimer's disease and healthy volunteers during a single test session. In the first phase of the session, participants are exposed to familiar songs, presented in sung, spoken or instrumental form, whose popularity they evaluate. In the second phase, they perform two implicit memory tasks: a trigram completion task and a lexical decision task. These tests measure the facilitation of the processing of words evoked by songs in relation to words unrelated to songs, reflecting a "long-term" memory update of mnemic traces of primed words.

Study Timeline

• Study First Submitted: 2017-11-10
• Study First Submitted QC: 2017-11-10
• Study First Posted: 2017-11-14
• Study Start: 2018-04-03
• Primary Completion: 2019-05-29
• Study Completion: 2019-05-29
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-09
• Last Update Posted: 2020-09-11

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
patient with Alzheimer's Disease	Music Experience Questionnaire	1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.
healthy volunteer	Questionnaires	1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not. 4. For volunteer over 65 years : Mini Mental State Examination, 5 words by Dubois and fluence verbal test
healthy volunteer	Implicit tasks memory	1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not. 4. For volunteer over 65 years : Mini Mental State Examination, 5 words by Dubois and fluence verbal test
healthy volunteer	Music Experience Questionnaire	1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not. 4. For volunteer over 65 years : Mini Mental State Examination, 5 words by Dubois and fluence verbal test
patient with Alzheimer's Disease	Exposure to familiar songs	1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.
patient with Alzheimer's Disease	Implicit tasks memory	1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.
healthy volunteer	Exposure to familiar songs	1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not. 4. For volunteer over 65 years : Mini Mental State Examination, 5 words by Dubois and fluence verbal test

Primary Outcome Measures

Name	Time	Method
Reaction time difference for the treatment of words that have been presented in sing condition in the exposure phase versus words presented in spoken condition.	Day 1

Secondary Outcome Measures

Name	Time	Method
Reaction time difference for processing words associated with songs presented by their melody alone versus new words (not presented in the exhibition phase).	Day 1

Trial Locations

Locations (1)

CHU de Saint Etienne; 🇫🇷 Saint-Étienne, France