跳至主要内容
临床试验/NCT03342326
NCT03342326终止不适用

Lexical Priming by Music in Alzheimer's Disease and Healthy Aging

Centre Hospitalier Universitaire de Saint Etienne2 个研究点 分布在 1 个国家目标入组 58 人开始时间: 2018年4月3日最近更新:
适应症

试验速览

阶段
不适用
状态
终止
入组人数
58
试验地点
2
主要终点
Reaction time difference for the treatment of words that have been presented in sing condition in the exposure phase versus words presented in spoken condition.

研究概览

简要总结

While verbal memory is quickly reached in the wake of Alzheimer's disease, the musical memory remains preserved until a late stage of the disease. This observation encouraged the development of music-based therapies in the management of neurocognitive and behavioral disorders that characterize Alzheimer's disease. In order to develop rehabilitation programs that effectively target cognitive functions to stimulate, it is necessary to understand the mechanisms underlying this beneficial effect of music on cognition.

详细描述

The investigators study the stimulation by the song, material integrating language and music, and having an autobiographical value. The investigators measure the lexical priming capacity of the song, that is, its ability to activate and maintain lexical and semantic representations, which are threatened with alteration in the course of the disease.

This lexical priming effect by song is measured in patients with mild Alzheimer's disease and healthy volunteers during a single test session. In the first phase of the session, participants are exposed to familiar songs, presented in sung, spoken or instrumental form, whose popularity they evaluate. In the second phase, they perform two implicit memory tasks: a trigram completion task and a lexical decision task. These tests measure the facilitation of the processing of words evoked by songs in relation to words unrelated to songs, reflecting a "long-term" memory update of mnemic traces of primed words.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Reaction time difference for the treatment of words that have been presented in sing condition in the exposure phase versus words presented in spoken condition.

时间窗: Day 1

次要结局

  • Reaction time difference for processing words associated with songs presented by their melody alone versus new words (not presented in the exhibition phase).(Day 1)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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