The prospective trial for the usefulness of hepatic vein arrival time using a microbubble contrast enhanced ultrasonography in non-invasive estimation of the severity of portal hypertension in cirrhotic patients

Not Applicable

Recruiting

• Conditions: Diseases of the digestive system

• Registration Number: KCT0000257
• Lead Sponsor: Yonsei University, Wonju Severance Christian Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

(1) Clinically definite liver cirrhosis patients or confirmed by liver biopsy
(2) Patients who evaluate portal hypertension by hepatic vein pressure gradient
(3) Patients who agree with enroll this study

Exclusion Criteria

(1) Baseline systolic blood pressure<90mmHg, heart rate<55rate/min
(2) Refractory ascites, hepatic encephalopathy, hepatorenal syndrome
(3) Hepatocellular carcinoma or other malignancy
(4) Cerebrovascular disease, uremia, sepsis or life-threatening disease
(5) Severe jaundice(serum total bilirubin>10mg/dL)
(6) Serum creatinine = 1.2mg/dL
(7) Past history of shunt procedure or TIPS
(8) Administration of beta-blocker, ACE inhibitor, nitrate within 1month
(9) Pregnancy
(10) Patients who disagree with enroll this study
(11) Patients who did not perform this study

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The relationship between HAVT and HVPG

Secondary Outcome Measures

Name	Time	Method
The mortality and variceal bleeding during 3years follow up;The variceal bleeding during 3years follow up