Difference in effect on post-meal lipid, proinsulin, GIP and GLP-1 between Sitagliptin, Vildagliptin and Alogliptin in T2DM using DPP-4 inhibitor

Not Applicable

• Conditions: Type 2 Diabetes Mellitus

• Registration Number: JPRN-UMIN000006217
• Lead Sponsor: Saitama Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-09-01
• Study Completion: 2012-07-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

1)Patients who use of other DPP4 inhibitor 2)Patients who use of fibrate 3)Diabetic neuropathy 4)Severe ketosis,deabetic coma or precoma,type1diabetes 5)Severe renal dysfunction requiring hemodialysis or peritoneal dialysis 6)Severe hepatic dysfunction 7)Patients with a history of hypersensitibity to the study drug 8)Patients before or after operation, and those with severe infections or serious injury 9)Pregnant 10)Patients judged by the investigator to be ineligible for some other reason

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ipid profile(pre-and post-meal(30min,1,2,3hours)triglyceride, pre- and post-meal(30min,1,2,3hours)chylomicron, pre- and post-meal(30min,1,2,3hours)VLDL, pre- and post-meal(30min,1,2,3hours)IDL, pre- and post-meal(30min,1,2,3hours)native LDL, pre- and post-meal(30min,1,2,3hours)small dense LDL, pre- and post-meal(30min,1,2,3hours)HD

Secondary Outcome Measures

Name	Time	Method
HbA1c, pre- and post-meal blood glucose(30min,1,2,3hours), pre-and post-meal(30min,1,2,3hours)insulin, pre- and post-meal(30min,1,2,3hours)proinsulin, pre- and post-meal(30min,1,2,3hours)C-peptide , pre- and post-meal(30min,1,2,3hours)GLP-1, pre- and post-meal(30min,1,2,3hours)GIP, pre- and post-meal(30min,1,2,3hours)glucagon