postprandial Lipidmetabolism in hMe subjects and healthy controls

Completed

• Conditions: postprandial dyslipidimia; postprandial lipidmetabolism disorder; 10083624; 10013317

• Registration Number: NL-OMON37127
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Male and female subjects at least 18 years of age
Clinically esthablished diagnosis of HME or unaffected, healthy control
willing to stop ATII/ACE inhibitors (5 days) and statin (4 weeks) before lipidload

Exclusion Criteria

Current diabetes
Current pregnancy
Malignancy with limited lifespan -Cardiovascular disease

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in postprandial trygliceride levels in HME subjects vewith either EXT1<br /><br>or EXT2 mutation compared to unaffected, healthy control subjects</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Changes in cardiovascular risk profile (lipidprofile, ECG changes) in HME<br /><br>subjects vewith either EXT1 or EXT2 mutation compared to unaffected, healthy<br /><br>control subjects</p><br>