Postprandial Intrahepatic Lipid (IHL) and Intramyocellular Lipid (IMCL) levels measured with Proton Magnetic Resonance Spectroscopy (1H-MRS)

Completed

• Conditions: fat accumulation in liver and muscle; Insulin resistance; 10018424

• Registration Number: NL-OMON39035
• Lead Sponsor: Maastricht University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

- Age 18-65 years
- Healthy
- Stable dietary habits
- No use of medication
- Lean subjects: BMI 18-25 kg/m2
- Obese subjects: BMI 30-35 kg/m2

Exclusion Criteria

- Any medical condition requiring treatment and/or medication use
- Alcohol consumption of more than 20 g per day (± 2 units)
- Smoking
- Unstable body weight (weight gain or loss > 3 kg in the past three months)
- Participation in another biomedical study within 1 month prior to the screening visit
- Contraindications for MRI scan (cochlear implant, pacemaker, claustrophobia)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The change of IHL and IMCL concentrations in the late postprandial phase,<br /><br>compared to baseline measurement after an overnight fast. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>We also aim to investigate whether the addition of protein to a high fat<br /><br>breakfast (HFP) results in a reduced postprandial accumulation of lipids when<br /><br>compared to a high fat breakfast (HF) alone. </p><br>