Postprandial Lipids in IBS and Nutritional Treatment

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

-IBS patients that meet the Rome IV criteria + additional criteria specific for
the diarrhea-predominant and mixed subtype: IBS-D and IBS-M
- Male and female adults, aged 18-70 years;
- Having a Body Mass Index (BMI) between 18.5 and 30 kg/m2;
- Willing to keep a stable dietary pattern throughout the study.

Exclusion Criteria

*Having a disease that may interfere with the outcomes of this study, such as a
known autonomic disorder, inflammatory bowel disease, coeliac disease, cancer,
dialysis patients, chronic kidney failure, depression or hypothyroidism.
* History of intestinal surgery (excluding appendectomy or cholecystectomy) or
endometriosis.
* Use of medication that can interfere with the study outcomes, including
codeine and antibiotics, as judged by the medical supervisor.
* Use of anticoagulants (as curcumin has inhibitory effects on platelet
aggregation).
* Use of prebiotics and/or probiotics (should be stopped 4 weeks before the
start of the study) and infrequent use of other supplements dedicated to bowel
function improvements. Some supplements are allowed (judged by medical
supervisor MD Ben Witteman) but intake should be kept stable during the whole
study period.
* Having swallowing problems with pills/capsules.
* Having a cow*s milk allergy or other food allergies.
* If applicable: currently pregnant or breastfeeding, or intending to become
pregnant during the study.
* Participation in another clinical trial at the same time.
* Student or employee working at Food, Health and Consumer Research from Food
and Biobased Research, or Department of Human Nutrition & Health, Wageningen
University.
* Alcohol intake * 14 (women) or * 28 (men) glasses of alcoholic beverages per
week.
* Smoking and abuse of illicit drugs, soft drugs, and/or nitrous oxide.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is blood LPS levels.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters are gastrointestinal complaints, and blood<br /><br>levels of LPS-related biomarkers.</p><br>

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