Postprandial bile acid metabolism in insulin sensitive and insulin resistant subjects: The Bile Acid Study

Completed

• Conditions: diabetes mellitus; 10025477; glucose intolerance; 10018424

• Registration Number: NL-OMON41585
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Healthy volunteers
or
Insulin resistant (HOMA-IR > 2.7)

Exclusion Criteria

*Use of medication that interferes with insulin metabolism (such as sulfonylureas, meglitinides, metformin, thiazolidenidiones, acarbose, dipeptidyl peptidase-4-inhibitors) or insulin.
*Use of medication that interferes with BA metabolism (colesevelam, colestimide, ursodeoxycholic acid).
Previous cholecystectomy
Weight increase or decrease >10% in previous 3 months
Alcohol use >2 units/day
Pregnancy and use of oral contraceptives in females

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference in postprandial bile acid levels in plasma, bile acid pool<br /><br>composition and bile acid kinetic parameters</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Changes in postprandial glucose kinetics and glucoregulatory hormones,<br /><br>activation of TGR5 and FXR mediated pathways in muscle and fat<br /><br>Resting energy expenditure<br /><br>Gastric emptying<br /><br>Adherence to diet<br /><br>Microbiome composition</p><br>