Characterization of intestinal bile acid metabolim in children with inflammatory bowel disease
Recruiting
- Conditions
- Pediatric inflammatory bowel diseaseK50K51Crohn disease [regional enteritis]Ulcerative colitis
- Registration Number
- DRKS00003580
- Lead Sponsor
- niversitätsklinik für Kinder- und Jugendheilkunde, Medizinische Universität Graz
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
Children and adolescent with suspicion to inflammatory bowel disease
Diagnosis of CU or UC on the basis of endoscopic and histological findings
Children and adolescent without histological findings serve as control group
Children and adolescent with follow-up colonoscopy (in case of known inflammatory bowel disease or other medical indication like familiary polyposis coli)
Age 6-19 years, male, female
Written inform consent (signature of parents / legal guardin)
Medical ability to undergo colonoscopy
Exclusion Criteria
Missing signature on written consent
Contraindication for colonoscopy with mucosal biopsies
Existing other severe disease (anemia, pathologic coagulation tests or anticoagulant medication etc.)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method This study investigate molecular expression level changes of different intestinal bile acid transporters, detoxifying systems and nuclear receptors in children and adolescent with inflammatory bowel disease. Therefore in intestinal biopsy specimens from children suffering from inflammatory bowel disease mRNA levels are investigated with the help of the real time PCR method (polymerase chain reaction).
- Secondary Outcome Measures
Name Time Method