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The physiological role of bile acid*mediated glucagon*like peptide*1 release in humans: the Cerebrotendinous Xanthomatosis Mixed Meal Test study

Completed
Conditions
bile acid synthesis defect
10027424
10018424
Registration Number
NL-OMON36008
Lead Sponsor
Academisch Medisch Centrum
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Completed
Sex
Not specified
Target Recruitment
28
Inclusion Criteria

*Adult age (older than 18 years of age)
*Body mass index 19*30 kg/m2
*General good health (normal liver and renal function)
*HbA1c below 7%
*Ability to give informed consent

Exclusion Criteria

Since CTX is a rare disorder, little exclusion criteria exist. However, patients that use
medication that interferes with glucose metabolism such as oral antidiabetic medication or
insulin are not included.

Study & Design

Study Type
Observational invasive
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
<p>Plasma bile acids, GLP-1, glucose</p><br>
Secondary Outcome Measures
NameTimeMethod
<p>free fatty acidsn,thyroid hormones, resting energy expenditure</p><br>
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