The physiological role of bile acid*mediated glucagon*like peptide*1 release in humans: the Cerebrotendinous Xanthomatosis Mixed Meal Test study
Completed
- Conditions
- bile acid synthesis defect1002742410018424
- Registration Number
- NL-OMON36008
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 28
Inclusion Criteria
*Adult age (older than 18 years of age)
*Body mass index 19*30 kg/m2
*General good health (normal liver and renal function)
*HbA1c below 7%
*Ability to give informed consent
Exclusion Criteria
Since CTX is a rare disorder, little exclusion criteria exist. However, patients that use
medication that interferes with glucose metabolism such as oral antidiabetic medication or
insulin are not included.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Plasma bile acids, GLP-1, glucose</p><br>
- Secondary Outcome Measures
Name Time Method <p>free fatty acidsn,thyroid hormones, resting energy expenditure</p><br>