Acute Effects of Natural and Interesterified Fats-margarine on Lipemic and Insulinemic Response

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Trans free palm margarine; Other: Interesterified Palm based margarine; Other: IE Soybean oil-based margarine

• Registration Number: NCT02194673
• Lead Sponsor: Malaysia Palm Oil Board

Brief Summary

Interesterified (IE) fat blends will respond differently in terms of postprandial lipemia and insulinemic responses compare to a trans free palm margarine (TFPM).

Detailed Description

The objective of this study was to investigate whether IE-fat blends behave differently on postprandial serum lipid, insulin, C-peptide and glucose concentration compare to TFPM. A randomised, double-blind crossover (3 × 3 arms) orthogonal Latin-square design was used and conducted on 10 males and 10 females adults. During postprandial challenge day, each subject received an a test muffin incorporated with test margarine. Blood samples were collected at half-hourly intervals until 4 hr by using cannulation technique.

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Study First Submitted: 2014-06-25
• Status Verified: 2014-07
• Study First Submitted QC: 2014-07-16
• Last Update Submitted: 2014-07-16
• Study First Posted: 2014-07-18
• Last Update Posted: 2014-07-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Body Mass Index (BMI) between 18.5 and 24.9
• <130mmHg for systolic pressure and <80 mmHg for diastolic pressure
• Blood glucose level in the range of 3.9 to 5.5 mmol/L
• Total cholesterol less than 5.17 mmol/L
• No use of tobacco and no consumption of alcohol.

Exclusion Criteria

• Suffer from chronic disease
• Metabolic syndrome
• Consuming any medical prescriptions
• People with blood clotting problem
• Women who are pregnant
• Hypertensive person

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Interesterified palm based margarine	Trans free palm margarine	One high fat muffin will be serves together with a glass of low fat milk shake.
Interesterified palm based margarine	Interesterified Palm based margarine	One high fat muffin will be serves together with a glass of low fat milk shake.
IE soybean oil-based margarine	Trans free palm margarine	One high fat muffin will be serves together with a glass of low fat milk shake.
Trans free palm margarine	IE Soybean oil-based margarine	One high fat muffin will be serves together with a glass of low fat milk shake.
Interesterified palm based margarine	IE Soybean oil-based margarine	One high fat muffin will be serves together with a glass of low fat milk shake.
Trans free palm margarine	Trans free palm margarine	One high fat muffin will be serves together with a glass of low fat milk shake.
Trans free palm margarine	Interesterified Palm based margarine	One high fat muffin will be serves together with a glass of low fat milk shake.
IE soybean oil-based margarine	Interesterified Palm based margarine	One high fat muffin will be serves together with a glass of low fat milk shake.
IE soybean oil-based margarine	IE Soybean oil-based margarine	One high fat muffin will be serves together with a glass of low fat milk shake.

Primary Outcome Measures

Name	Time	Method
Change in serum triglycerides level of subjects as a measure of postprandial triglycerides response	Baseline, 4 hours

Secondary Outcome Measures

Name	Time	Method
Change in the level of plasma insulin, c-peptide and serum glucose as a measure of postprandial insulinemic response	Baseline, 4 hours

Trial Locations

Locations (1)

MalaysiaPOB; 🇲🇾 Kajang, Selangor, Malaysia