Non-invasive Ventilation in Covid-19 Respiratory Failure - Predicting Success: A Retrospective Observational Study to Determine Predictive Factors in the Success or Failure of Non-invasive Ventilation.
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Clinical Improvement
研究概览
简要总结
A retrospective, single centre observational study to validate use of the HACOR score (Duan et al, 2017) in determining efficacy of non-invasive ventilation in Covid-19 respiratory failure.
详细描述
The investigators will retrospectively analyse medical records of patients with confirmed Covid-19 respiratory failure who received continuous positive airway pressure (CPAP) via facemask, as per clinician decision, in the High Dependency Unit (HDU) or Intensive Care Unit (ICU) of University Hospital Crosshouse between 1st March 2020 and 30th April 2021. By collecting baseline demographics and physiological data (including APACHE II and clinical frailty score) and calculating the HACOR score at initiation of CPAP, then at 1hr, 6hrs, 12hrs, 24hrs and 48hrs after initiating CPAP the investigators aim to validate use of the HACOR score in determining efficacy of NIV in Covid-19 respiratory failure. The investigators will also collect other variables (CRP and lymphocytes, lactate, mean arterial pressure, temperature) to determine if these factors have utility in predicting efficacy of NIV in Covid-19 respiratory failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed Covid-19 respiratory failure
- •NIV treatment instituted as per clinician decision
- •Admitted to HDU or ICU between 1/3/20 and 30/4/21
排除标准
- •Patients with immediate indication for invasive ventilation
- •Patients whose primary diagnosis was not Covid-19 respiratory failure, but received NIV in that time period
结局指标
主要结局
Clinical Improvement
时间窗: Up to 6 months
Number of patients who improved after NIV commenced, resulting in liberation from NIV (without requiring invasive ventilation)
Escalation to Invasive Ventilation
时间窗: Up to 6 months
Number of patients who deteriorated after NIV commenced, requiring escalation to invasive ventilation
Death Due to Respiratory Failure
时间窗: Up to 6 months
Number of patients who deteriorated after NIV commenced, resulting in death due to respiratory failure
次要结局
未报告次要终点
研究者
Jamie Hooker
Senior Clinical Fellow, Intensive Care
National Heatlh Service Ayrshire and Arran