Effectiveness of Homoeopathic medicines in Allergic Common Cold
- Conditions
- Allergic rhinitis due to food, (2) ICD-10 Condition: J301||Allergic rhinitis due to pollen, (3) ICD-10 Condition: J309||Allergic rhinitis, unspecified, (4) ICD-10 Condition: J308||Other allergic rhinitis, (5) ICD-10 Condition: J302||Other seasonal allergic rhinitis, (6) ICD-10 Condition: J300||Vasomotor rhinitis,
- Registration Number
- CTRI/2020/05/025141
- Lead Sponsor
- Vinayaka Missions Research Foundation Deemed to be University
- Brief Summary
Allergic rhinitis is aninflammatory disorder of the nasal mucosa induced by allergen exposuretriggering IgE-mediated inflammation. Clinically, it is characterized by fourmajor symptoms–rhinorrhea, sneezing, nasal itching, and nasal congestion. Itcan also be associated with co-morbid conditions as Asthma, Atopic Dermatitis& Nasal polyps. Around 20–30 % of the Indian population suffers fromallergic rhinitis and that 15 % develop asthma. Allergic Rhinitis symptomsresult in sleep disturbance, fatigue, depressed mood and cognitive functioncompromise that impairs quality of life and productivity.
A number ofpharmacologic interventions are prescribed to treat Allergic Rhinitis.Intranasal corticosteroids (INC) are recommended in current guidelines asfirst-line therapy for patients with moderate to severe Allergic Rhinitis,particularly when nasal congestion is the prominent symptom.
Preservatives in theINC formulation may produce nasal irritation and may impart unacceptable taste or odour to theformulation. Further, the relative osmotic pressure or tonicity of theformulation can modulate nasal retention and absorption, thereby potentiallyinfluencing clinical efficacy.1 The use of INC may tend to causeadverse effects like a stinging or burning sensation in the nose, dryness andcrustiness in the nose, a dry, irritated throat, an unpleasant tastein the mouth, itchiness, redness and swelling in the nose, [nosebleeds](https://www.nhs.uk/conditions/nosebleed/),etc.,Furthermore INC could relieve the Nasal Congestion only thattoo for a limited time period. They don’t play a role in modulating theimmunity of the patient, Prevention or Cure of the Allergic Rhinitis.
The Diagnosis of Allergic Rhinitis is based onTypical history of allergic symptoms ‘‘sneezers and runners’’. All patientswith persistent allergic rhinitis need a nasal examination (Anteriorrhinoscopy, Nasal endoscopy). The diagnostic tests are directed towards thedetection of free or cell bound IgE. Immediate hypersensitivity skin tests arewidely used to demonstrate an IgE-mediated allergic reaction. These represent amajor diagnostic tool in the field of allergy. The measurement ofallergen-specific IgE (radioallergosorbent testing, RAST) in serum is ofimportance and is of similar value to skin tests. They are more useful inpatients having dermatitis, dermographism, and in cases where antihistamineshave to be continued during testing.
Various Clinical Trialsconducted by ‘CCRH, New Delhi’ and other reputed institutions across globe havedemonstrated the efficacy of Homoeopathic management of Allergic Rhinitis.Homoeopathic Medicines like Allium cepa, Sabadilla, Aurum triphyllum,Euphrasia, Hepar sulphuris, Arsenicum iodatum, Kalium iodatum, etc., are foundto be effective in treating Allergic Rhinitis by Previous Studies.
Lesser known drugs like*Galphimia glauca.6C, Luffa operculata.6C &Penthorum Sedoides.6C*are also found to beclinically effective in treating Allergic Rhinitis by literature survey. Buttheir effect on modulation of Elevated Serum Immunoglobulin-E levels inAllergic Rhinitis patients is not yet explored by any of the Researches acrossthe World.
These details intendedme to do a comparative experimental study on the effectiveness of the three saidmedicines in the modulation of Serum Immunoglobulin-E levels in AllergicRhinitis patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
- Clinically Diagnosed patients of Allergic Rhinitis patients with Serum Immunoglobulin.
- E Level ≥ 158 IU/mL or as per the reference range in other Units / for other laboratory methods.
- Allergic Rhinitis with Systemic infection or Complications.
- Patients with Occupational Health Hazards or Repeated Exposure.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Symptomatic Relief of Allergic Rhinitis Symptoms. 90 Days Reduction in Serum IgE Levels. 90 Days
- Secondary Outcome Measures
Name Time Method NA NA
Trial Locations
- Locations (1)
Vinayaka Missions Homoeopathic Medical College and Hospital
🇮🇳Salem, TAMIL NADU, India
Vinayaka Missions Homoeopathic Medical College and Hospital🇮🇳Salem, TAMIL NADU, IndiaDr H VenkatesanPrincipal investigator9865134561venkathompath@gmail.com