Exploring the Cortical Hemodynamic Variability of Prefrontal iTBS: a Concurrent TBS/fNIRS Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- The Hong Kong Polytechnic University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Oxygenated hemoglobin (HbO) change compared to baseline
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
An increasing number of studies have used the intermittent theta-burst stimulation (iTBS) protocol to investigate neural plasticity non-invasively in the prefontal cortex in healthy humans and in patients with psychiatric disorders. However, the variability in the neurophysiological response to iTBS stimulation is high. The cause of this variability is multifactorial and to some degree still unknown. Therefore, the current study explores inter- and intra-individual factors that are potentially moderating iTBS-induced excitability changes. A greater understanding of these determinants would be highly valuable for optimizing the therapeutic application of iTBS.
Detailed Description
The investigators will measure the cortical excitability induced by iTBS with concurrent TBS/fNIRS technique in the same healthy individuals on multiple testing days. Meanwhile, several potential inter- (age, gender, etc.) and intra-individual factors (daily mood, daily physical activity levels, etc.) recently identified in non-invasive transcranial brain stimulation studies will be assessed before applying iTBS to the same individual on each testing day.
Investigators
Dr Georg Kranz
Assistant Professor
The Hong Kong Polytechnic University
Eligibility Criteria
Inclusion Criteria
- •healthiness based on history and psychiatric assessment
- •being able to hear and understand the verbal instructions
- •completed at least 6 years of formal education
Exclusion Criteria
- •a current or past diagnosis of psychiatric, neurological disorders, or severe internal illness
- •any conditions that will contraindicate to iTBS or fNIRS
- •psychiatric disorders in their first-degree relatives
- •pregnancy
Outcomes
Primary Outcomes
Oxygenated hemoglobin (HbO) change compared to baseline
Time Frame: During and post TBS-fNIRS measurement, up to 3 months
iTBS-induced HbO change in the DLPFC before, during and after stimulation
Secondary Outcomes
- Oxygen saturation change compared to baseline(During and post TBS-fNIRS measurement, up to 3 months)
- Deoxygenated hemoglobin (HbR) change compared to baseline(During and post TBS-fNIRS measurement, up to 3 months)