NCT06545994招募中不适用
A Prospective Cohort Study on the Dynamic Monitoring of Serum Kisspeptin Levels Throughout Pregnancy and Exploring Its Predictive Value for Gestational Diabetes Mellitus in PCOS Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Dynamic changes of serum kisspeptin levels throughout pregnancy in PCOS patients
研究概览
简要总结
The current study aims to investigate the dynamic serum kisspeptin levels throughout pregnancy and to explore its predictive value for GDM in PCOS.
详细描述
The current prospective cohort study aims to investigate the dynamic serum kisspeptin levels in the patients with polycystic ovary syndrome (PCOS) at different trimesters of pregnancy, to analyze the associations between serum kisspeptin, insulin, glucose and testosterone, and to explore the predictive value of kisspeptin for GDM and other complications in PCOS patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age between 18 and 40 years old
- •Women diagnosed as PCOS who register for prenatal check ups in the obstetrics outpatient department of hospitals during early pregnancy.(The diagnostic criteria for PCOS are based on the 2003 Rotterdam diagnostic criteria (any two out of the three key characteristics of PCOS: oligo-amenorrhea, hyperandrogenism, and polycystic-appearing ovarian morphology on ultrasonography) .
排除标准
- •All other diseases with ovulation disorders or hyperandrogenism
结局指标
主要结局
Dynamic changes of serum kisspeptin levels throughout pregnancy in PCOS patients
时间窗: 40 weeks
Serum kisspeptin levels in the first, second trimester and late pregnancy of PCOS patients and control group.
次要结局
- The association between serum Kisspeptin levels and the prevalence of GDM in PCOS patients(40 weeks)
- The association between serum Kisspeptin levels and the prevalence of insulin resistance in PCOS patients(40 weeks)
研究者
研究点 (1)
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