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3D Non-invasive Myocardial Electrical Propagation Mapping as a New Tool to Predict Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy

Not Applicable
Completed
Conditions
Hypertrophic Cardiomyopathy
Interventions
Device: CardioInsight™ Noninvasive 3D Mapping System
Registration Number
NCT03550573
Lead Sponsor
Hospices Civils de Lyon
Brief Summary

Hypertrophic cardiomyopathy (HCM) is very common. The thickened heart muscle can disrupt the normal functioning of the heart's electrical system, resulting in fast or irregular heartbeats. Today, there are no reliable means to identify HCM patients at risk of sudden death. The CardioInsight™ has recently been developed by Medtronic for non-invasive advanced cardiac mapping system. The CardioInsight™ Noninvasive 3D Mapping System is a non-invasive mapping system that collects chest ECG signals and combines these signals with CT scan data to produce and display simultaneous, bi-atrial and biventricular, 3-D cardiac maps.

It is a monocentric, prospective, comparative and analytical study. 20 HCM patients will be recruited in the National Reference Center for inherited cardiac diseases of Lyon. The 3D-propagation maps of 10 well phenotyped and genotyped HCM patients with previous VF (ventricular fibrillation) will be compared to 10 HCM patients without previous VF.

After consent signed, Holter ECG, scanner and CardioInsightTM 3D_ECG mapping will be planned in the month following the inclusion. 12-lead ECG, 24h holter ECG, cardiac scanner will be performed as standard procedure of each center in the current health care of the patient.

The widespread screening of HCM patients with 3D high-density noninvasive mapping should improve the risk-benefit ratio of implantable defibrillator therapy. It is expected that more patients at risk will benefit from this device.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
30
Inclusion Criteria

Not provided

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Exclusion Criteria
  • pregnant women,
  • left ventricular dilation (diastolic >60 mm diameter) and/or left ventricular systolic dysfunction (LVEF <55%),
  • prior cardiac surgery,
  • atrial fibrillation,
  • renal disease (serum creatinine >2.0 mg/dl),
  • primary cardiac valve disease
  • coronary artery disease
  • Previous recent cardiac scan
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
hypertrophic cardiomyopathy with sudden death historyCardioInsight™ Noninvasive 3D Mapping System-
hypertrophic cardiomyopathy without sudden death historyCardioInsight™ Noninvasive 3D Mapping System-
Primary Outcome Measures
NameTimeMethod
Identification of specific markers of risk of sudden death in HCM patients from the maps created by the combination of CT and signal data.Month 1

The CardioInsight system uses a proprietary, single-use, disposable multi-electrode vest to capture electrical signals from the body surface. The CardioInsight software provides various cardiac signal analyses and displays interactive 3-D color maps including activation, voltage, composite and phase maps. The use of the CardioInsight system is correlated with a CT scan.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Hôpital Louis Pradel

🇫🇷

Bron, France

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