Short-term Effects of a Carob Snack on Postprandial Glycemic Responses and Energy Intake and Satiety

Not Applicable

Completed

• Conditions: Potential Abnormality of Glucose Tolerance; Appetite; Lack or Loss, Nonorganic Origin

• Registration Number: NCT02935829
• Lead Sponsor: Agricultural University of Athens

Brief Summary

This study investigated any potential associations between two preloads offered as snacks and postprandial glycemic response, subjective and objective appetite and energy intake in healthy, normal-weight adults.

Detailed Description

This study aimed at 1. firstly determine the glycemic index (GI) of a carob snack compared with an isoenergetic, equal weight chocolate cookie and 2. test the hypothesis that a carob preload consumed as snack before a meal, compared to chocolate cookie would: (a) have greater short-term effect on satiety measured by subsequent ad libitum meal intake, (b) induce greater satiety as assessed by visual analogue scales (VAS), and (c) reduce postprandial glycemic response.

Study Timeline

• Study Start: 2014-03
• Primary Completion: 2015-12
• Study First Submitted: 2016-05-24
• Study Completion: 2016-09
• Study First Submitted QC: 2016-10-14
• Study First Posted: 2016-10-18
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-19
• Last Update Posted: 2017-01-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• Healthy, non-smoking, non-diabetic men and women individuals with normal body mass index (BMI; between 18.5 and 24.9 kg/m2)

Exclusion Criteria

• Severe chronic disease (e.g. tumors, manifest coronary heart disease, diabetes mellitus, severe kidney or liver conditions, endocrine and immunological conditions)
• Gastrointestinal disorders (e.g. chronic inflammatory bowel disease)
• Lactose intolerance
• Pregnancy
• Competitive sports
• Lactation
• Alcohol
• Drug dependency

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Capillary blood glucose and subjective appetite ratings	7 hours	Clinically useful change in serum glucose, defined as the restoration of glucose within normal limits during the 2hr glucose tolerance test. Useful change in subjective appetite (hunger, desire to eat, motivation to eat, preoccupation with thoughts of food, thirst) scores from 100mm VAS

Secondary Outcome Measures

Name	Time	Method
Subjective appetite ratings	6 hours	Useful change in subjective appetite (hunger, desire to eat, motivation to eat, preoccupation with thoughts of food, thirst) scores from 100mm VAS
Energy intake after preload	2 hours	Useful change in energy intake the day of the intervention (actual weighing of foods consumed and leftovers and 24hr recall)
Energy intake next 24hours	2 days	Useful change in energy intake in the next 24hr (24hr recall) after intervention

Trial Locations

Locations (1)

Agricultural University of Athens; 🇬🇷 Athens, Greece