NL-OMON25245已完成不适用
Optimizing timing of glucocorticoid treatment in children with congenital adrenal hyperplasia
Radboudumc, Department of pediatric endocrinology0 个研究点目标入组 50 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Children and adolescents with CAH due to 21-hydroxylase deficiency > 4 years old
- •The diagnosis is confirmed by mutation analysis
- •Patient are treated with hydrocortisone according to standard guidelines in a thrice daily schedule
- •Ability to collect saliva
排除标准
- •Other forms of CAH
- •Not able to collect saliva
- •Chronical medication use other than hydrocortisone and fludrocortisone
研究者
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Optimizing timing of glucocorticoid treatment in children with congenital adrenal hyperplasiaCAHNL-OMON48168Radboud Universitair Medisch Centrum50
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Avoiding over and undertreatment by optimizing of the timing ofglucocorticoïd treatment in children with cnogenital adrenal hyperplasiaCongenital adrenal hyperplasia (CAH) is a disorder of adrenal steroidsynthesis leading to cortisol deficiency and an increase in androgenproduction.Treatment in children consists of hydrocortisone substitutionthereby also restoring the negative feedback on the pituitary gland andconsequently normalize androgen production. There is still no evidenceabout the best timing of hydrocortisone use: The highest dosage ofhydrocortisone in the morning or the highest dosage at nightEUCTR2018-004802-24-NLRadboud University Nijmegen Medical Centre50
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