To study the effects of 2 standard treatment-timing strategies for glucocorticoïd dosage on androgen concentration in CAH childre
Completed
- Conditions
- Congenital adrenal hyperplasia (AGS)
- Registration Number
- NL-OMON25245
- Lead Sponsor
- Radboudumc, Department of pediatric endocrinology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
•Children and adolescents with CAH due to 21-hydroxylase deficiency > 4 years old
•The diagnosis is confirmed by mutation analysis
•Patient are treated with hydrocortisone according to standard guidelines in a thrice daily schedule
•Ability to collect saliva
Exclusion Criteria
•Other forms of CAH
•Not able to collect saliva
•Chronical medication use other than hydrocortisone and fludrocortisone
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concentrations of salivary 17OHP and A after 3 weeks of treatment with the 2 different timing strategies.
- Secondary Outcome Measures
Name Time Method 12 Hours blood pressure and activity and sleeping patters during the 2 treatment strategies.