NCT04821219撤回不适用
Establishing a Platform for Personalized Approach to the Management of Pancreatic Adenocarcinoma Using Patient-Derived Tumoroids
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- Mayo Clinic
- 主要终点
- Rate of the successful establishment of pancreatic patient-derived tumoroids (PDT)
研究概览
简要总结
This study is designed to prospectively investigate the feasibility of establishing patient-derived tumoroids (PDT) as a platform for a personalized approach for response prediction and guide optimal neoadjuvant and/or adjuvant approach. PDT will be investigated to determine drug sensitivity, predict the response to chemotherapy agents and radiation therapy, and validate this response in treated patients, and to establish the feasibility of PDT as a platform for a personalized approach to guide multimodality treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years of age.
- •Have an ECOG Performance Status of ≤
- •No evidence of distant metastasis on imaging.
- •Histologic or cytologic proven adenocarcinoma of the pancreas.
- •Providing informed consent prior to enrollment in the trial.
排除标准
- •Failure to obtain additional core needle biopsies for generating PDTs.
- •Females who are pregnant or plan to become pregnant.
结局指标
主要结局
Rate of the successful establishment of pancreatic patient-derived tumoroids (PDT)
时间窗: 2 years
次要结局
- PDT validation with a comparative analysis of patients' response to neoadjuvant chemotherapy and radiation(2 years)
- Drug sensitivity and response prediction of radiation therapy in PDT(2 years)
- Drug sensitivity and response prediction of chemotherapy agents in PDT(2 years)
研究者
Panagiotis Z. Anastasiadis
Principal Investigator
Mayo Clinic
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