Circulating tumour cells by diagnostic leukapheresis mirror primary tumour heterogeneity in non-small cell lung cancer
- Conditions
- circulating tumour cells (CTC)Non small cell lung carcinoma (NSCLC)Diagnostic leukapheresis (DLA)tumour heterogeneitycirculerende tumor cellen (CTC)niet kleincellig long carcinoom (NSCLC)diagnostische leukopherese (DLA)tumor heterogeniteit
- Registration Number
- NL-OMON19904
- Lead Sponsor
- Sponsor: Innovative Medicine initiativeperformer: UMCG
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Patients with a histologically proven pulmonary malignancy (all disease stages)
Performance status 0-2
Exclusion Criteria
Patients with insufficient peripheral venes to undergo leukapheresis
Haemorrhagic diathesis: recent CVA, major bleeding, ulcus duodeni
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of CTC's and percentage of patients who had CTC's detected. And comparing the CTC detection percentage per disease stage (stage I-IV). <br>
- Secondary Outcome Measures
Name Time Method survival and mutations measured in the CTC's and the original tumour.