Spontaneous Breathing Trial: an evaluation of applicability in patients depending on home mechanical ventilatio

• Conditions: J96.1; Chronic respiratory failure

• Registration Number: DRKS00006744
• Lead Sponsor: ungenklink - Abt. Pneumologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-09-15
• Study Completion: 2015-08-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Signed consent form
• Patients aged = 18 years
• Intermittent invasive ventilation therapy via a tracheostoma
• invasive home mechanical ventilation therapy = 2 months
• Stable period of disease (no complaint deterioration in the last two weeks, no evidence of respiratory infection)
• accomplishment of the criteria for readiness to wean

Exclusion Criteria

• Patients aged <18 years
• Continuous invasive ventilation therapy
• worsening of symptoms in the last 2 weeks, evidence for respiratory infection (at least 2 criteria: Purulent sputum, fever, infiltration in the chest X-ray, leukocytes> 10,000 / L)
• Non-fulfillment of the criteria for readiness to wean

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rapid Shallow Breathing Index (RSBI=Breathing rate/tidal volume); measured continously by a pneumotachograph; start with disconection of the ventilator, end when finishing or after 120 minutes<br>

Secondary Outcome Measures

Name	Time	Method
Respiratory Rate, tidal volume (continously via pneumotachograph), SpO2, PtcCO2, PaO2, PaCO2, pH (capillary bloodgas analysis; before start, after 30 minutes, when finishing or after 120 minutes), blood pressure (every 15 minutes), heart rate (continously via Sentec), subjective dyspnea (Borg-Dyspnoe-Scala, every 30 minutes)