Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity

Completed

• Conditions: Obesity
• Interventions: Procedure: Fat Biopsy

• Registration Number: NCT01900366
• Lead Sponsor: Rockefeller University

Brief Summary

This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.

Detailed Description

Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.

Study Timeline

• Study First Submitted: 2013-07-11
• Study First Submitted QC: 2013-07-11
• Study First Posted: 2013-07-16
• Study Start: 2013-08
• Primary Completion: 2016-08
• Study Completion: 2016-08
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-16
• Last Update Posted: 2016-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

-Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol

Exclusion Criteria

-History of any skin disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Obese subjects for fat biopsy	Fat Biopsy	10 patients recruited during fat biopsies for sample collection
Lean controls for fat biopsy	Fat Biopsy	5 Lean controls will be recruited

Primary Outcome Measures

Name	Time	Method
Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy	1 day	Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy

Secondary Outcome Measures

Name	Time	Method
Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy	1 day	Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy

Trial Locations

Locations (1)

The Rockefeller University; 🇺🇸 New York, New York, United States