A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
- Conditions
- Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
- Interventions
- Drug: Giredestrant-matched PlaceboDrug: Letrozole-matched PlaceboDrug: LHRH Agonist
- Registration Number
- NCT04546009
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This Phase III, randomized, double-blind, placebo-controlled, multicenter study will evaluate the efficacy and safety of giredestrant combined with palbociclib compared with letrozole combined with palbociclib in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2)-negative locally advanced (recurrent or progressed) or metastatic breast cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 992
- For women who are premenopausal or perimenopausal and for men: treatment with approved LHRH agonist therapy for the duration of study treatment
- Locally advanced (recurrent or progressed) or metastatic adenocarcinoma of the breast, not amenable to treatment with curative intent
- Documented ER-positive tumor and HER2-negative tumor, assessed locally
- Patients who have bilateral breast cancers which are both ER-positive and HER2-negative can be included in the study because the metastases are suitably targeted by the study treatments. If patients have bilateral tumors which are of different biomarker status, then proof of the ER and HER2 status of the metastases is required for study entry
- No history of systemic anti-cancer therapy for locally advanced (recurrent or progressed) or metastatic disease
- Disease recurrence from early-stage breast cancer after standard adjuvant endocrine therapy meeting the protocol-defined criteria of having received at least 24 months of treatment without disease progression during treatment and a disease-free interval since the completion of treatment that was greater than 12 months
- Measurable disease as defined per RECIST v.1.1 or bone only disease which must have at least one predominantly lytic bone lesion confirmed by CT or MRI which can be followed
- Eastern Cooperative Oncology Group Performance Status 0-1
- Adequate organ function
- Disease recurrence during or within 12 months of completing prior neoadjuvant or adjuvant treatment with any CDK4/6 inhibitor
- Prior treatment with a selective estrogen receptor degrader (SERD)
- Treatment with any investigational therapy within 28 days prior to study treatment
- Treatment with strong CYP3A inhibitors or inducers within 14 days or 5 drug elimination half-lives (whichever is longer) prior to randomization
- Advanced, symptomatic, visceral spread that is at risk of life-threatening complications in the short term
- Known active uncontrolled or symptomatic CNS metastases, carcinomatous meningitis, or leptomeningeal disease
- Active cardiac disease or history of cardiac dysfunction, as defined in the protocol
- Pregnant or breastfeeding
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Giredestrant + Letrozole-matched Placebo + Palbociclib Letrozole-matched Placebo - Giredestrant + Letrozole-matched Placebo + Palbociclib Palbociclib - Giredestrant + Letrozole-matched Placebo + Palbociclib LHRH Agonist - Letrozole + Giredestrant-matched Placebo + Palbociclib Giredestrant-matched Placebo - Letrozole + Giredestrant-matched Placebo + Palbociclib Letrozole - Letrozole + Giredestrant-matched Placebo + Palbociclib Palbociclib - Letrozole + Giredestrant-matched Placebo + Palbociclib LHRH Agonist - Giredestrant + Letrozole-matched Placebo + Palbociclib Giredestrant -
- Primary Outcome Measures
Name Time Method Progression-Free Survival (PFS), as Determined by the Investigator According to RECIST v1.1 From randomization to the first occurrence of disease progression or death from any cause, whichever occurs first (up to 78 months)
- Secondary Outcome Measures
Name Time Method Overall Survival From randomization to death from any cause (up to 78 months) Objective Response Rate, as Determined by the Investigator According to RECIST v1.1 From randomization until disease progression or death (up to 78 months) The objective response rate is defined as the percentage of participants with a complete response or partial response on two consecutive occasions at least (≥)4 weeks apart.
Duration of Response, as Determined by the Investigator According to RECIST v1.1 From first occurrence of documented objective response to disease progression or death from any cause, whichever occurs first (up to 78 months) Clinical Benefit Rate, as Determined by the Investigator According to RECIST v1.1 From randomization until disease progression or death (up to 78 months) The clinical benefit rate is defined as the percentage of participants with stable disease for ≥24 weeks or a complete response or partial response.
Time to Confirmed Deterioration in Pain Level, Defined as the Time to First Documented ≥2-Point Increase from Baseline in the 'Worst Pain' Item from the Brief Pain Inventory-Short Form (BPI-SF) Questionnaire From Baseline until treatment discontinuation (up to 78 months) Time to Confirmed Deterioration in Pain Presence and Interference, Defined as the Time to First Documented ≥10-Point Increase from Baseline in the EORTC QLQ-C30 Linearly Transformed Pain Scale Score From Baseline until treatment discontinuation (up to 78 months) EORTC QLQ-C30 = European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire
Time to Confirmed Deterioration in Physical Functioning, Defined as the Time to First Documented ≥10-Point Decrease from Baseline in the EORTC QLQ-C30 Linearly Transformed Physical Functioning Scale Score From Baseline until treatment discontinuation (up to 78 months) Time to Confirmed Deterioration in Role Functioning, Defined as the Time to First Documented ≥10-Point Decrease from Baseline in the EORTC QLQ-C30 Linearly Transformed Role Functioning Scale Score From Baseline until treatment discontinuation (up to 78 months) Time to Confirmed Deterioration in Global Health Status and Quality of Life (GHS/QoL), Defined as the Time to First Documented ≥10-Point Decrease from Baseline in the EORTC QLQ-C30 Linearly Transformed GHS/QoL Scale Score From Baseline until treatment discontinuation (up to 78 months) Number of Participants with Adverse Events, Severity Determined According to National Cancer Institute Common Terminology Criteria for Adverse Events, Version 5.0 (NCI-CTCAE v5.0) From treatment initiation until 30 days after the final dose of study treatment (up to 78 months) Number of Participants with Vital Sign Abnormalities Over the Course of the Study Baseline, Days 1 and 15 of Cycles 1 and 2, and Day 1 of each cycle thereafter until treatment discontinuation (1 cycle is 28 days) Vital signs include respiratory rate, pulse rate, and systolic and diastolic blood pressure while the participant is in a seated position, and temperature.
Plasma Concentration of Giredestrant at Specified Timepoints Days 1 and 15 of Cycle 1; Day 1 of Cycles 2, 4, 8, and 16 (1 cycle is 28 days) Plasma Concentration of Palbociclib at Specified Timepoints Days 1 and 15 of Cycle 1 (1 cycle is 28 days)
Trial Locations
- Locations (262)
Peter MacCallum Cancer Centre-East Melbourne
🇦🇺Melbourne, Victoria, Australia
Sunshine Hospital
🇦🇺St Albans, Victoria, Australia
Fiona Stanley Hospital - Medical Oncology
🇦🇺Murdoch, Western Australia, Australia
Uniklinikum Salzburg, LKH
🇦🇹Salzburg, Austria
A.Ö. LHK
🇦🇹Steyr, Austria
Medizinische Universität Wien
🇦🇹Wien, Austria
Cliniques Universitaires St-Luc
🇧🇪Bruxelles, Belgium
Jessa Zkh (Campus Virga Jesse)
🇧🇪Hasselt, Belgium
Hospital Sao Rafael - HSR
🇧🇷Salvador, Bahia, Brazil
Hospital Araujo Jorge
🇧🇷Goiania, Goiás, Brazil
Hospital do Cancer de Pernambuco - HCP
🇧🇷Recife, Pernambuco, Brazil
Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Sao Lucas - PUCRS
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital de Base de Sao Jose do Rio Preto
🇧🇷Sao Jose do Rio Preto, São Paulo, Brazil
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda
🇧🇷Sao Paulo, São Paulo, Brazil
Beneficencia Portuguesa de Sao Paulo
🇧🇷Sao Paulo, São Paulo, Brazil
Arthur J.E. Child Comprehensive Cancer Center-Calgary
🇨🇦Calgary, Alberta, Canada
BC Cancer ? Surrey
🇨🇦Surrey, British Columbia, Canada
Royal Victoria Regional Health Centre
🇨🇦Barrie, Ontario, Canada
William Osler Health System Brampton Civic Hospital
🇨🇦Brampton, Ontario, Canada
Ottawa Hospital Research Institute
🇨🇦Ottawa, Ontario, Canada
Princess Margaret Cancer Center
🇨🇦Toronto, Ontario, Canada
Universite de Montreal - Hopital Maisonneuve-Rosemont
🇨🇦Montreal, Quebec, Canada
Centre Hospitalier de l?Université de Montréal (CHUM)
🇨🇦Montreal, Quebec, Canada
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
McGill University Health Center
🇨🇦Montreal, Quebec, Canada
Hopital du Saint Sacrement
🇨🇦Quebec City, Quebec, Canada
Anyang Tumor Hosptial
🇨🇳Anyang City, China
Affiliated Hospital of Hebei University
🇨🇳Baoding, China
Beijing Cancer Hospital
🇨🇳Beijing, China
the First Affiliated Hospital of Bengbu Medical College
🇨🇳Bengbu City, China
The First Hospital of Jilin University
🇨🇳Changchun City, China
Hunan Cancer Hospital
🇨🇳Changsha City, China
Fujian Medical University Union Hospital
🇨🇳Fujian, China
Sun Yat-sen Memorial Hospital
🇨🇳Guangzhou, China
Sun Yet-sen University Cancer Center
🇨🇳Guangzhou, China
Sir Run Run Shaw Hospital Zhejiang University
🇨🇳Hangzhou City, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, China
Shandong Cancer Hospital
🇨🇳Jinan, China
Guangxi Cancer Hospital of Guangxi Medical University
🇨🇳Nanning, China
Shengjing Hospital of China Medical University
🇨🇳ShenYang, China
Liaoning cancer Hospital & Institute
🇨🇳Shenyang, China
The First Affiliated Hospital of Xian Jiao Tong University
🇨🇳Xi'an City, China
Herlev Hospital
🇩🇰Herlev, Denmark
Sjællands Universitetshospital, Næstved
🇩🇰Naestved, Denmark
Odense Universitetshospital, Onkologisk Afdeling R
🇩🇰Odense C, Denmark
ICO Paul Papin
🇫🇷Angers, France
Centre Hospitalier de La Cote Basque
🇫🇷Bayonne, France
Chd de Vendee
🇫🇷La Roche Sur Yon, France
Institut régional du Cancer Montpellier
🇫🇷Montpellier, France
Chu La Miletrie
🇫🇷Poitiers, France
Institut Jean Godinot
🇫🇷Reims CEDEX, France
Centre Eugene Marquis
🇫🇷Rennes, France
ICL
🇫🇷Saint-Priest en Jarez, France
Centre Alexis Vautrin
🇫🇷Vandoeuvre Les Nancy, France
Ambulantes Tumorzentrum Spandau
🇩🇪Berlin, Germany
Klinikum Chemnitz gGmbH
🇩🇪Chemnitz, Germany
Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden
🇩🇪Dresden, Germany
Universitätsklinikum Essen
🇩🇪Essen, Germany
Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH
🇩🇪Georgsmarienhütte, Germany
Dres.Andreas Ammon und Dirk Meyer
🇩🇪Göttingen, Germany
Universitätsklinikum Hamburg-Eppendorf
🇩🇪Hamburg, Germany
Facharztzentrum Eppendorf, Studien GbR
🇩🇪Hamburg, Germany
Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie
🇩🇪Hannover, Germany
Nationales Centrum für Tumorerkrankungen (NCT)
🇩🇪Heidelberg, Germany
Praxis Köppler, Heymann, Weide, Thomalla
🇩🇪Koblenz, Germany
Dres. Andreas Köhler und Roswitha Fuchs
🇩🇪Langen, Germany
St. Elisabeth-Krankenhaus, Senologie/Brustzentrum
🇩🇪Leipzig, Germany
Universitätsklinikum Mannheim
🇩🇪Mannheim, Germany
Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt
🇩🇪München, Germany
MVZ für Hämatologie und Onkologie Ravensburg GmBH
🇩🇪Ravensburg, Germany
Klinikum Mutterhaus der Borromaeerinnen gGmbH
🇩🇪Trier, Germany
Dres. Helmut Forstbauer, Carsten Ziske und Kollegen
🇩🇪Troisdorf, Germany
Universitätsklinik Tübingen
🇩🇪Tübingen, Germany
Anticancer Hospital Ag Savas
🇬🇷Athens, Greece
Anticancer Hospital Ag. Savas
🇬🇷Athens, Greece
Euromedical General Clinic of Thessaloniki
🇬🇷Thessaloniki, Greece
Pamela Youde Nethersole Eastern Hospital
🇭🇰Hong Kong, Hong Kong
Princess Margaret Hospital
🇭🇰Hong Kong, Hong Kong
Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong
Honvédelmi Minisztérium Állami Egészségügyi Központ;Onkológiai Osztály
🇭🇺Budapest, Hungary
Orange Coast Memorial Medical Center
🇺🇸Fountain Valley, California, United States
Budapesti Uzsoki Utcai Kórház
🇭🇺Budapest, Hungary
Davidof Center - Rabin Medical Center
🇮🇱Petah Tiqwa, Israel
Long Beach Memorial Medical Center
🇺🇸Long Beach, California, United States
Kaiser Permanente - San Leandro Medical Center
🇺🇸San Leandro, California, United States
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Tel Aviv Sourasky Medical Ctr
🇮🇱Tel Aviv, Israel
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola
🇮🇹Meldola, Emilia-Romagna, Italy
IRCCS Istituto Regina Elena (IFO)
🇮🇹Roma, Lazio, Italy
Az. Osp. Spedali Civili
🇮🇹Brescia, Lombardia, Italy
Istituto Europeo Di Oncologia
🇮🇹Milano, Lombardia, Italy
Asst Di Monza
🇮🇹Monza, Lombardia, Italy
Humanitas Centro Catanese Di Oncologia
🇮🇹Misterbianco (CT), Sicilia, Italy
Ospedale Civile - Livorno
🇮🇹Livorno, Toscana, Italy
Fondazione del Piemonte per l?Oncologia (IRCCS)
🇮🇹Candiolo, Trentino-Alto Adige, Italy
Ospedale Sacro Cuore Don Calabria
🇮🇹Negrar, Veneto, Italy
IOV - Istituto Oncologico Veneto - IRCCS
🇮🇹Padova, Veneto, Italy
Azienda ULSS 8 Berica
🇮🇹Vicenza, Veneto, Italy
Nagoya University Hospital
🇯🇵Aichi, Japan
Chiba Cancer Center
🇯🇵Chiba, Japan
National Cancer Center Hospital East
🇯🇵Chiba, Japan
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka, Japan
Hiroshima City Hiroshima Citizens Hospital
🇯🇵Hiroshima, Japan
Stanford Univ Medical Center
🇺🇸Stanford, California, United States
Kaiser Permanente - Vallejo
🇺🇸Vallejo, California, United States
Kaiser Permanente - Walnut Creek
🇺🇸Walnut Creek, California, United States
University of Colorado
🇺🇸Aurora, Colorado, United States
Rocky Mountain Cancer Center
🇺🇸Denver, Colorado, United States
Florida Cancer Specialists - Fort Myers (Broadway)
🇺🇸Fort Myers, Florida, United States
SCRI Florida Cancer Specialists North
🇺🇸Saint Petersburg, Florida, United States
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
National Hospital Organization Hokkaido Cancer Center
🇯🇵Hokkaido, Japan
Hyogo Cancer Center
🇯🇵Hyogo, Japan
University of Tsukuba Hospital
🇯🇵Ibaraki, Japan
Sagara Hospital
🇯🇵Kagoshima, Japan
Kanagawa Cancer Center
🇯🇵Kanagawa, Japan
Tokai University Hospital
🇯🇵Kanagawa, Japan
Kumamoto University Hospital
🇯🇵Kumamoto, Japan
Fukushima Medical University Hospital
🇯🇵Miyagi, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata, Japan
Naha-nishi Clinic
🇯🇵Okinawa, Japan
Memorial Regional Cancer Ctr
🇺🇸Hollywood, Florida, United States
SCRI Florida Cancer Specialists PAN
🇺🇸Tallahassee, Florida, United States
Kaiser Permanente - Moanalua Medical Center
🇺🇸Honolulu, Hawaii, United States
Mercy Medical Center
🇺🇸Baltimore, Maryland, United States
National Hospital Organization Osaka National Hospital
🇯🇵Osaka, Japan
Osaka International Cancer Institute
🇯🇵Osaka, Japan
Saitama Cancer Center
🇯🇵Saitama, Japan
National Cancer Center Hospital
🇯🇵Tokyo, Japan
The Cancer Institute Hospital of JFCR
🇯🇵Tokyo, Japan
Showa University Hospital
🇯🇵Tokyo, Japan
Chungbuk National University Hospital
🇰🇷Cheongju-si, Korea, Republic of
Kyungpook National University Medical Center
🇰🇷Daegu, Korea, Republic of
National Cancer Center
🇰🇷Gyeonggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Gangnam Severance Hospital
🇰🇷Seoul, Korea, Republic of
University of Miami
🇺🇸Miami, Florida, United States
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Ulsan University Hosiptal
🇰🇷Ulsan, Korea, Republic of
Health Pharma Professional Research
🇲🇽CD Mexico, Mexico CITY (federal District), Mexico
Centro Medico Dalinde
🇲🇽Cdmx, Mexico CITY (federal District), Mexico
Filios Alta Medicina
🇲🇽Monterrey, Nuevo LEON, Mexico
Centro de Investigacion Clinica de Oaxaca
🇲🇽Oaxaca de Juárez, Oaxaca, Mexico
Oncologico Potosino
🇲🇽San Luis Potosí, SAN LUIS Potosi, Mexico
Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde
🇲🇽Morelia, Mexico
Sociedad de Metabolismo y Corazón (SOMECO)
🇲🇽Veracruz, Mexico
Auckland City Hospital
🇳🇿Auckland, New Zealand
Oncosalud Sac
🇵🇪Lima, Peru
Instituto Peruano de Oncología y Radioterapia
🇵🇪Lima, Peru
Instituto Nacional de Enfermedades Neoplasicas
🇵🇪Lima, Peru
Clinica Ricardo Palma
🇵🇪San Isidro, Peru
Instituto Regional de Enfermedades Neoplasicas - IREN Norte
🇵🇪Trujillo, Peru
Uniwersyteckie Centrum Kliniczne
🇵🇱Gda?sk, Poland
Szpital Morski im. PCK
🇵🇱Gdynia, Poland
Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad
🇵🇱Warszawa, Poland
IPO de Coimbra
🇵🇹Coimbra, Portugal
Hospital da Luz
🇵🇹Lisboa, Portugal
Centro Hospitalar Lisboa Norte
🇵🇹Lisboa, Portugal
IPO do Porto
🇵🇹Porto, Portugal
Maryland Oncology Hematology
🇺🇸Silver Spring, Maryland, United States
Respublikanskiy Onkologicheskiy Dispanser
🇷🇺Saransk, Mordovija, Russian Federation
SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"
🇷🇺Moskva, Moskovskaja Oblast, Russian Federation
Podolsk City Clinical Hospital
🇷🇺Podolsk, Moskovskaja Oblast, Russian Federation
Ryazan Regional clinical oncology dispensary
🇷🇺Ryazan, Rjazan, Russian Federation
GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology)
🇷🇺Saint Petersburg, Sankt Petersburg, Russian Federation
Chelyabinsk region oncology dispensary
🇷🇺Chelyabinsk, Russian Federation
Multidisciplinary clinic Reaviz
🇷🇺Samara, Russian Federation
Regional Clinical Oncology Hospital
🇷🇺Yaroslavl, Russian Federation
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Hospital Duran i Reynals
🇪🇸L' Hospitalet DE Llobregat, Barcelona, Spain
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
HCA Midwest Division
🇺🇸Kansas City, Missouri, United States
Memorial Sloan Kettering Cancer Center Basking Ridge
🇺🇸Basking Ridge, New Jersey, United States
Astera Cancer Care East Brunswick
🇺🇸East Brunswick, New Jersey, United States
Memorial Sloan Kettering - Monmouth
🇺🇸Middletown, New Jersey, United States
Memorial Sloan Kettering Cancer Center at Bergen
🇺🇸Montvale, New Jersey, United States
San Juan Oncology Associates
🇺🇸Farmington, New Mexico, United States
MSKCC @ Commack
🇺🇸Commack, New York, United States
Memorial Sloan Kettering Cancer Center at Westchester
🇺🇸Harrison, New York, United States
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Memorial Sloan Kettering Cancer Center at Nassau
🇺🇸Uniondale, New York, United States
Corporacio Sanitaria Parc Tauli
🇪🇸Sabadell, Barcelona, Spain
Hospital de Donostia
🇪🇸San Sebastian, Guipuzcoa, Spain
Hospital Quiron de Madrid
🇪🇸Pozuelo de Alarcon, Madrid, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Universitari Dexeus - Grupo Quironsalud
🇪🇸Barcelona, Spain
Vall d?Hebron Institute of Oncology (VHIO), Barcelona
🇪🇸Barcelona, Spain
Complejo Hospitalario Universitario A Coruña (CHUAC)
🇪🇸La Coruna, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
Centro Oncologico MD Anderson Internacional
🇪🇸Madrid, Spain
Hospital Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
HM Sanchinarro ? CIOCC
🇪🇸Madrid, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung Uni Hospital
🇨🇳Tainan, Taiwan
Veterans General Hospital
🇨🇳Taipei, Taiwan
National Taiwan Uni Hospital
🇨🇳Taipei, Taiwan
Mackay Memorial Hospital
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hosipital at Linkou
🇨🇳Taoyuan Hsien, Taiwan
The Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Providence Portland Medical Ctr
🇺🇸Portland, Oregon, United States
Chulalongkorn Hospital, Faculty of Medicine
🇹🇭Bangkok, Thailand
Roper St. Francis Healthcare
🇺🇸Charleston, South Carolina, United States
West Cancer Center
🇺🇸Germantown, Tennessee, United States
Rajavithi Hospital
🇹🇭Bangkok, Thailand
Ramathibodi Hospital
🇹🇭Bangkok, Thailand
Maharaj Nakorn Chiang Mai Hosp
🇹🇭Chang Mai, Thailand
Songklanagarind Hospital
🇹🇭Songkhla, Thailand
Hacettepe Uni Medical Faculty Hospital
🇹🇷Ankara, Turkey
Ankara Bilkent City Hospital
🇹🇷Ankara, Turkey
Sarah Cannon Research Institute / Tennessee Oncology
🇺🇸Nashville, Tennessee, United States
Texas Oncology - DFW
🇺🇸Dallas, Texas, United States
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
🇹🇷Edirne, Turkey
Medipol University Medical Faculty
🇹🇷Istanbul, Turkey
Medeniyet University Goztepe Training and Research Hospital.
🇹🇷Istanbul, Turkey
The Center for Cancer and Blood Disorders - Fort Worth
🇺🇸Fort Worth, Texas, United States
Baylor St. Luke's Medical Center
🇺🇸Houston, Texas, United States
Houston Methodist Hospital
🇺🇸Houston, Texas, United States
Inova Fairfax Hospital
🇺🇸Fairfax, Virginia, United States
Virginia Oncology Associates
🇺🇸Norfolk, Virginia, United States
Northwest Medical Specialties
🇺🇸Tacoma, Washington, United States
University of Wisconsin
🇺🇸Madison, Wisconsin, United States
Hospital de Onc Angel Roffo
🇦🇷Buenos Aires, Argentina
Fundación CENIT para la Investigación en Neurociencias
🇦🇷Buenos Aires, Argentina
Organización medica de Investi
🇦🇷Cap fed, Argentina
Hospital Britanico
🇦🇷Ciudad Autonoma Bs As, Argentina
Hospital Provincial del Centenario
🇦🇷Rosario, Argentina
Instituto de Oncología de Rosario
🇦🇷Rosario, Argentina
CEMER Centro Medico de Enfermedades Respiratorias
🇦🇷Vicente López, Argentina
Katip Celebi University Ataturk Training and Research Hospital
🇹🇷Izmir, Turkey
Calvary Mater Newcastle
🇦🇺Waratah, New South Wales, Australia
Mater Hospital Brisbane
🇦🇺South Brisbane, Queensland, Australia
Kocaeli University Faculty of Medicine
🇹🇷Izmit, Turkey
Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department
🇹🇷Malatya, Turkey
19 Mayis University Medical Faculty
🇹🇷Samsun, Turkey
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Municipal Institution City Clinical Hospital #4 of Dnipro City Council
🇺🇦Dnipropetrovsk, Katerynoslav Governorate, Ukraine
SI Institute of general&urgent surgery n/a Zaytseva V.T NAMSU
🇺🇦Kharkiv, Kharkiv Governorate, Ukraine
Ivano-Frankivsk Regional Oncology Center
🇺🇦Ivano-Frankivsk, Ukraine
ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council
🇺🇦Kryvyi Rih, Ukraine
Sumy Regional Clinical Onc Ctr
🇺🇦Sumy, Ukraine
Uzhgorod Central City Clinical Hospital
🇺🇦Uzhhorod, Ukraine
Royal Sussex County Hospital
🇬🇧Brighton, United Kingdom
Leicester Royal Infirmary
🇬🇧Leicester, United Kingdom
University College London Hospital
🇬🇧London, United Kingdom
Royal Free Hospital
🇬🇧London, United Kingdom
Guys & St Thomas Hospital
🇬🇧London, United Kingdom
Royal Marsden Hosp NHS Fnd
🇬🇧Sutton, United Kingdom
Maidstone Hospital
🇬🇧Maidstone, United Kingdom
Peterborough City Hospital
🇬🇧Peterborough, United Kingdom
Derriford Hospital
🇬🇧Plymouth, United Kingdom
Royal Cornwall Hospital
🇬🇧Truro, United Kingdom