Mechanisms of Cardiovascular Dysfunction and Effect of Aerobic Exercise Training in Adults With Type 2 Diabetes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Type 2 Diabetes
- Sponsor
- University of Florida
- Enrollment
- 116
- Locations
- 1
- Primary Endpoint
- Change in vascular endothelial function
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The study objectives are:
- To compare cardiovascular function in type 2 diabetes patients vs. healthy controls.
- To compare the effect of 8 weeks of aerobic interval training versus continuous moderate exercise on cardiovascular function in adults with type 2 diabetes.
- To examine the mechanisms underlying the exercise-related changes in cardiovascular function.
The investigators hypothesize that compared to continuous moderate intensity exercise training, interval training will be more effective in improving cardiovascular function in adults with type 2 diabetes.
Detailed Description
Cardiovascular function will be measured at baseline in adults with type 2 diabetes and in age-matched healthy controls. Research volunteers with type 2 diabetes who meet the inclusion criteria will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week randomized control exercise intervention, baseline measures will be repeated.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •History of diabetic proliferative retinopathy, autonomic or peripheral neuropathy
- •History of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)
- •Hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)
- •History of renal impairment
- •History of gout or hyperuricemia
- •History of hepatic disease or infection with hepatitis B, C
- •History of seizures, or other relevant on-going or recurrent illness
- •Recent (within 3 months) or recurrent hospitalizations
- •Use of tobacco products
- •\>5 % weight change in the prior 6 months.
Outcomes
Primary Outcomes
Change in vascular endothelial function
Time Frame: At baseline and after 8 weeks of exercise training
Brachial flow mediated dilation using ultrasonography
Secondary Outcomes
- Change in cardiac function(At baseline and after 8 weeks of exercise training)
- Change in factors related with endothelial function(At baseline and after 8 weeks of exercise training)
- Change in arterial stiffness(At baseline and after 8 weeks of exercise training)
- Change in maximal oxygen consumption(At baseline and after 8 weeks of exercise training)