Exercise and Irisin Trial (EXIT): Prospective Cohort Study of the Determinants of the Metabolic Response to Exercise in Obese Adolescents
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Hepatic Triglyceride Content
研究概览
简要总结
Background :
Regular exercise is a cornerstone in the prevention and the management of comorbidities. Unfortunately, the metabolic benefit of exercise training is not universal and varies among individuals. A main factor likely to explain the exercise training variability is the lack of empirical evidence on the determinants of exercise training. A series of muscle-derived cytokines have recently been discovered that (1) are released during exercise and (2) exert positive effects on peripheral tissues. Irisin is one of these novel "myokines" and might contributes to the metabolic adaptations to exercise training.
Methods:
The investigators will perform a pilot cohort study in which obese adolescents will perform resistance exercise training for 6 weeks. The main exposure variable will be the acute release of irisin during resistance exercise. The main outcome measures will be the change in hepatic triglyceride content and glucose area under the curve during a 75g, 2-hour oral glucose tolerance test.
Study Hypothesis:
The primary overall hypothesis is that the change in plasma Irisin with a single bout of exercise will be associated with the metabolic adaptations to 6 weeks of resistance training, specifically, the reductions in hepatic triglyceride content and post-prandial glucose excursions, in obese adolescents.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adolescents (12-18 years)
- •Body mass index considered obese according to the International Obesity Task Force
排除标准
- •Adolescents with medication-induced or type 1 diabetes
- •are currently being treated with corticosteroids or atypical antipsychotics, as these agents significantly influence carbohydrate metabolism
- •have an orthopaedic injury or chronic illness that would prevent them from performing the intervention
- •have experienced >10% weight loss or enrolled in weight loss program within six months of enrolment
- •a history of alcoholism or drug abuse
- •require use of medication(s) known to affect insulin sensitivity or secretion within the last 30 days
- •medication(s) known to cause weight gain
- •anabolic steroids
- •weight loss medication(s)
- •pregnant or planning to be pregnant
结局指标
主要结局
Hepatic Triglyceride Content
时间窗: 6 weeks
Hepatic triglyceride content will be measured by using 1H magnetic resonance spectroscopy. After image acquisition, a single voxel volume of interest will be placed in the upper right lobe of the liver in an area devoid of adipose tissue to acquire 1H spectra. A total of 64 spectra will be collected and averaged to determine the intracellular triglyceride content.
次要结局
- Post-prandial glucose(6 weeks)
研究者
Jon McGavock
Associate Professor Department of Pediatrics and Child Health
University of Manitoba