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Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation

Not yet recruiting
Conditions
Alveolar Bone Grafting
Bone Healing
Tooth Extraction Site Healing
Wound Healing
Interventions
Other: observational study
Registration Number
NCT06624982
Lead Sponsor
Marquette University
Brief Summary

The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Detailed Description

The null hypothesis for this study is that there is no difference in bone ridge width and height changes 4 months following extraction and alveolar ridge preservation at sites that undergo immediate post-extraction socket expansion or no immediate post-extraction ridge width change. Patients of the Graduate Periodontics Clinic at Marquette University School of Dentistry scheduled for extraction, bone graft and resorbable membrane will be recruited for this study.

After providing informed consent and prior to local anesthesia and extraction, the following parameters will be recorded: age, gender, race, medical history, medications, tooth site, reason for extraction and tooth mobility. Gingival width will be recorded prior to local anesthesia and extraction, and at 4 months. Gingival thickness will be recorded after local anesthesia and prior to extraction, and at 4 months. Buccolingual ridge width and ridge height will be recorded immediately before, immediately after extraction, and at 4 months. Immediately after extraction, the following measurements will be recorded: buccal bone thickness, number of roots, root length and width, instruments used for extraction, need for flap elevation, duration of extraction, anesthetic amount, type and approach, and operator experience.

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
160
Inclusion Criteria
  • Adult patients (18-75 years)
  • Good general health (controlled conditions)
  • Controlled periodontal disease
  • Scheduled for single tooth extraction with bone graft placement and resorbable membrane
  • Tooth to be extracted must have adjacent teeth
  • Socket wall integrity
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Exclusion Criteria
  • Smoking
  • Pregnancy
  • Active periodontal disease
  • Systemic conditions that affect healing
  • Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Non-molar sites with immediate post-extraction ridge expansionobservational studyNon-molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.
Non-molar sites with no immediate post-extraction ridge width changeobservational studyNon-molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.
Molar sites with immediate post-extraction ridge expansionobservational studyMolar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.
Molar sites with no immediate post-extraction ridge width changeobservational studyMolar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.
Primary Outcome Measures
NameTimeMethod
Buccolingual ridge width(1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

Buccolingual ridge width will be measured through a stent via ridge mapping calipers. The measurement locations will be at 1mm, 3mm and 5mm from the midbuccal crest. The same measurements will be recorded at all selected time points.

Ridge height(1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

Ridge height will be measured through a stent via a periodontal probe as the distance between bone and predetermined landmarks on the stent. The measurement locations will be mesial buccal, midbuccal, distal buccal, mesial lingual, midlingual and distal lingual. The same measurements will be recorded at all selected time points.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Marquette University School of Dentistry Graduate Periodontics Clinic

🇺🇸

Milwaukee, Wisconsin, United States

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