Epidural Nalbuphine for Postcesarean Epidural Morphine Induced Pruritus
- Registration Number
- NCT00707824
- Lead Sponsor
- Mahidol University
- Brief Summary
Can epidural nalbuphine reduce incidence or severity of epidural morphine induced pruritus in patient undergoing cesarean section?
- Detailed Description
182 parturients,ASA 1-2 undergoing cesarean section under epidural block were enrolled in the study. After obtaining informed consent,all received epidural anesthesia using 2% lidocaine with epinephrine 1:200000 via epidural cathetes at L2-3 or L3-4 in a volume suffient to achieve a T4 sensory level bilaterally.
After the umbilical cord was clamped,patients were assigned randomly to three groups.The placebo group,N-5 group,and N-10 group received 4 ml epidural solution containing morphine 4 mg plus either saline, nalbuphine 5 mg, and nalbuphine 10 mg respectively.At the post anesthetic care unit, intravenous pethidine PCA were administered for inadequate pain control.
Outcome measures :
Incidence and severity of postoperative pruritus Quality of pain control Side effects of epidural morphine and nalbuphine such as respiratory depression,sedation
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 165
- full term parturient undergoing elective cesarean section
- ASA 1-2
- drug or alcohol abuses
- contraindication for regional anesthesia
- received opioids within 12 hours
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description 1 NSS 1= placebo 2 nalbuphine 2=nalbuphine 5 mg 3 nalbuphine 3=nalbuphine 10 mg
- Primary Outcome Measures
Name Time Method incidence and severity of pruritus 24 hr
- Secondary Outcome Measures
Name Time Method visual analogue pain score 24 hr
Trial Locations
- Locations (1)
Mahidol University
🇹🇭Bangkoknoi, Bangkok, Thailand