Nalbuphine

Generic Name
Nalbuphine
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C21H27NO4
CAS Number
20594-83-6
Unique Ingredient Identifier
L2T84IQI2K
Background

A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.

Indication

For the relief of moderate to severe pain.

Associated Conditions
Severe Pain, Moderate Pain, Obstetrical analgesia therapy
Associated Therapies
Perioperative analgesia, Obstetric analgesia
Clinical Trials
Related News

Comparative Study of Opioid-Free Anesthesia Versus Opioid Anesthesia in Patients Undergoing Laparoscopic Cholecystectomy

Phase 4
Not yet recruiting
Conditions
Laparoscopic Cholecystectomy
Interventions
Drug: Nalbuphine
Drug: Dexmedetomidine
First Posted Date
2024-12-16
Last Posted Date
2024-12-16
Lead Sponsor
Assiut University
Target Recruit Count
100
Registration Number
NCT06736496

Comparison of the Efficacy of Intraperitoneal Instillation of Fentanyl Versus Nalbuphine As Adjuvants to Bupivacaine for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy

Phase 4
Not yet recruiting
Conditions
Laparoscopic Cholecystectomy
Interventions
Drug: fentanyl
Drug: Nalbuphine
First Posted Date
2024-12-09
Last Posted Date
2024-12-09
Lead Sponsor
Assiut University
Target Recruit Count
70
Registration Number
NCT06722963

Comparsion Between Intrathecal Fentanyl and Intravenous Nalbuphine As a Postoperative Analgesia in Lower Limb Surgeries

Phase 4
Not yet recruiting
Conditions
Lower Limb Surgery
Interventions
Drug: fentanyl
Drug: Nalbuphine
First Posted Date
2024-12-06
Last Posted Date
2024-12-06
Lead Sponsor
Assiut University
Target Recruit Count
100
Registration Number
NCT06720506

Comparison of IV Nalbuphine Versus Ibuprofen for Postoperative Pain Control in Cesarean Section

Not Applicable
Completed
Conditions
Pain Management
Interventions
Drug: Ibuprofen
Drug: Nalbuphine
First Posted Date
2024-09-13
Last Posted Date
2024-09-13
Lead Sponsor
Muhammad Aamir Latif
Target Recruit Count
80
Registration Number
NCT06594224
Locations
🇵🇰

Nishtar Hospital, Multan, Punjab, Pakistan

🇵🇰

Nishtar Medical University, Multan, Punjab, Pakistan

Nalbuphine as Adjuvant During Bilateral Suprazygomatic Maxillary Nerve Block for Pediatric Cleft Palate Repair

Not yet recruiting
Conditions
Complication Following Peripheral Nerve Block
Interventions
Drug: Nalbuphine
First Posted Date
2023-10-25
Last Posted Date
2024-08-01
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT06100315

Nalbuphine in ARDS Patients After Surgery

First Posted Date
2023-09-14
Last Posted Date
2024-03-13
Lead Sponsor
Hairong Chen
Target Recruit Count
60
Registration Number
NCT06037330
Locations
🇨🇳

Department of Intensive Care Medicine, Jinan, Shandong, China

Analgesic Additives to Epidural Bupivacaine in Normal Labor

Not Applicable
Not yet recruiting
Conditions
Labor Pain
Interventions
Drug: Dexmedetomidine
Drug: fentanyl
Drug: Nalbuphine
First Posted Date
2023-02-27
Last Posted Date
2023-02-27
Lead Sponsor
Assiut University
Target Recruit Count
69
Registration Number
NCT05746351

Dexmedetomidine Versus Nalbuphine as an Adjuvant to Intrathecal Bupivacaine

Not Applicable
Completed
Conditions
Analgesia
Interventions
Drug: Dexmedetomidine
Drug: Nalbuphine
First Posted Date
2022-04-26
Last Posted Date
2024-03-15
Lead Sponsor
Mansoura University
Target Recruit Count
60
Registration Number
NCT05347173
Locations
🇪🇬

Mansoura University-Emergency hospital-ICU, El Dakahlia, Mansoura, Egypt

Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia

First Posted Date
2022-04-14
Last Posted Date
2022-04-14
Lead Sponsor
Ain Shams University
Target Recruit Count
64
Registration Number
NCT05327088
Locations
🇪🇬

Ain Shams University, Cairo, Egypt

Nalbuphine Versus Dexmedetomidine for Prevention of Emergence Agitation in Pediatrics

First Posted Date
2022-03-10
Last Posted Date
2022-04-08
Lead Sponsor
Alexandria University
Target Recruit Count
126
Registration Number
NCT05273671
Locations
🇪🇬

Alexandria university, Alexandria, Egypt

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