Effect of Shorten Gonadotropin-releasing Hormone Agonist Therapy on the Outcome of in Vitro Fertilization-Embryo Transfer in Patients With Endometriosis

Not Applicable

• Conditions: Clinical Pregnancy Rate
• Interventions: Drug: Long term GnRH-a (3.75mg)

• Registration Number: NCT03006406
• Lead Sponsor: The First Affiliated Hospital of Zhengzhou University

Brief Summary

Gonadotropin-releasing hormone analogue (GnRH-a) is a synthetic decapeptide compound which can down-regulate pituitary function causing a temporary low estrogen state. Since endometriosis is an estrogen-dependent disease, the use of long-acting GnRH-a can control the growth of endometriosis by inhibiting ovary function.Some scholars have found that, for adenomyosis patients who received a super long protocol (pretreatment of long-acting GnRH-a for 1-2 months) in IVF treatment, the pregnancy outcome is comparable to that of the controls with normal uterus. Thus, the aim of this study is to compare the clinical pregnancy rate in patients treated with GnRH-a for 1, or 2 months.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01
• Status Verified: 2016-12
• Study First Submitted: 2016-12-28
• Study First Submitted QC: 2016-12-29
• Last Update Submitted: 2016-12-29
• Study First Posted: 2016-12-30
• Last Update Posted: 2016-12-30
• Primary Completion: 2017-01
• Study Completion: 2018-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• first IVF cycle;
• with normal ovarian reserve(FSH(10miu/ml； antral follicle count )3)
• with normal uterine

Exclusion Criteria

• Pre-implantation genetic diagnosis cycles;
• Oocyte donation cycles

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Long term GnRH-a for 1 month	Long term GnRH-a (3.75mg)	patient in this group only receive GnRH-a 3.75 for 1 month
patient in this group only receive GnRH-a 3.75 for 2 month	Long term GnRH-a (3.75mg)	patient in this group only receive GnRH-a 3.75 for 2 month

Primary Outcome Measures

Name	Time	Method
clinical pregnancy rate	5 weeks after embryo transfer

Secondary Outcome Measures

Name	Time	Method
Number of oocytes retrieved	1 day at oocyte retrieved day
2 pronucleus(2PN)fertilization rate	48hours after oocyte retrieved day	Number of 2PN/Matured oocytes

Trial Locations

Locations (1)

Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University; 🇨🇳 Zhengzhou, Henan, China