Molecular and Imaging Studies of Cardiovascular Health and Disease

Recruiting

• Conditions: Hypertrophic Cardiomyopathy; Ischemic Heart Disease; Healthy; Dilated Cardiomyopathy
• Interventions: Other: Cardiovascular Magnetic Resonance; Other: Fatmass measurement

• Registration Number: NCT02804269
• Lead Sponsor: National Heart Centre Singapore

Brief Summary

Biobank is a program which collects biological samples, health information and imaging data from consented patients and stored them at the core facility. These information would be used to study the molecular, imaging and outcome studies of cardiovascular health and disease.

Detailed Description

This program recruits patient from National Heart Centre Singapore and collects their biological sample, health information and imaging data.The donated biospecimens will be stored indefinitely and used for any future research on molecular, imaging and outcome studies of cardiovascular health and disease.The same biological samples and imaging data will be obtained from consented healthy volunteers for comparison.

Study Timeline

• Status Verified: 2013-07
• Study Start: 2013-07
• Study First Submitted: 2016-05-31
• Study First Submitted QC: 2016-06-14
• Last Update Submitted: 2016-06-14
• Study First Posted: 2016-06-17
• Last Update Posted: 2016-06-17
• Primary Completion: 2033-07
• Study Completion: 2033-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

•Subject aged ≥ 16 years and ≤ 90 years.

Exclusion Criteria

•No

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Hypertrophic cardiomyopathy	Cardiovascular Magnetic Resonance	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Ischemic heart disease with reduced EF	Fatmass measurement	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Hypertrophic cardiomyopathy	Fatmass measurement	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Ischemic heart disease with normal EF	Cardiovascular Magnetic Resonance	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Ischemic heart disease with normal EF	Fatmass measurement	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Dilated Cardiomyopathy	Fatmass measurement	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Healthy Volunteer	Cardiovascular Magnetic Resonance	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Ischemic heart disease with reduced EF	Cardiovascular Magnetic Resonance	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Healthy Volunteer	Fatmass measurement	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Dilated Cardiomyopathy	Cardiovascular Magnetic Resonance	Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement

Primary Outcome Measures

Name	Time	Method
Numbers of genetic variation in genes known to cause inherited cardiac condition and circulating biomarkers which are linked with DNA changes using advanced sequencing and informatics approaches	10 years

Trial Locations

Locations (1)

National Heart Centre Singapore; 🇸🇬 Singapore, Singapore